LiFE: Leading Innovation for the Future Ecosystem in Haemophilia

We are interested in initiatives that strengthen the generation, collection, harmonisation, or application of meaningful clinical data in haemophilia A, with two focus areas:

• Development of new endpoints beyond bleeding rates (ABR), with a pathway toward regulatory and payer acceptance

• Registry initiatives addressing relevant current and future evidence gaps

Please note:

• Investigator-initiated studies (i.e. as interventional trials) are out of scope for LiFE.

We welcome projects that support education, capability building, and development of the future workforce in haemophilia care.

Examples may include:

• Educational initiatives focused on evolving care models

• Programs addressing aging and comorbidities

• Musculoskeletal health and physical activity programs

• Multidisciplinary care education

• Training initiatives for future treaters and researchers

• Practical educational tools supporting implementation of innovation into care

Please note:

• Non-Clinical Education (general professional development, business administration qualifications , or non-healthcare-specific skills training) is out of scope for LiFE.

We encourage initiatives that help translate advances in science into practical improvements in clinical care.

Examples may include:

• Multidisciplinary care pathways

• Monitoring and follow-up frameworks

• Clinical decision-support tools

• Models supporting personalized care approaches

• Tools that support coordination across care teams

Please note: 

• Treatment guidelines are out of scope for LiFE

A signed letter from the applying organisation addressed to:

F. Hoffmann-La Roche
LtdGrenzacherstrasse 124
4070 Basel
Switzerland

The letter should include:

• Name of the applying organisation

• Address, city, zip/postal code, and country

• Name and email address of the main contact person

• Amount requested from Roche

• Total project budget and budget breakdown

• Proposed benefits for Roche - if any- and/or any in-kind / non-monetary support from Roche needed -if any.

• Start and end dates of the proposed activity, where applicable

• Venue details, where applicable

• Signature and date from an authorised representative of the organisation

Applicants should provide the project outline including:

• Focus Area: Data and Evidence, Education and Workforce Capability, Guidance and Practical Tools for Optimal Patient Management

• Scientific and Clinical Rationale: Referenced rationale detailing the scientific, clinical, or structural basis of the project.

• Problem Statement, Unmet Need, and Differentiation: A description of the specific, unaddressed gap in Haemophilia A care that this initiative aims to resolve and unique differentiating value it offers.

• Project Methodology and Implementation Plan: Description of the technical approach, the project timelines and roles, responsibilities, and decision-making structures.

• Financial Overview and Justification: Selected Funding Tier, total amount requested,  and budget breakdown.

• Expected Outcomes, Success Metrics, and Performance Indicators.

• Project Personnel Qualifications and Experience.

• Additional Indicators, where applicable: Multi-Stakeholder Value. Scalability and/or replicability strategy. Long term sustainability Plan.

Where applicable, applicants may also include:

• Draft agenda or program

• Additional supporting documentation

• Description of anticipated target audience and stakeholder reach

• Description of any planned visibility or collaboration elements related to Roche support, if applicable

LiFE supports initiatives that address structural or practical gaps in haemophilia A across three categories:

• Data and Evidence, with a focus on registries and new endpoints with a path to regulatory and payer acceptance.

• Education and Workforce Capability

• Guidance and Tools for Optimal Patient Management

Both new initiatives and existing projects seeking support for expansion or broader implementation may be considered.

The following are generally out of scope:

• Independent Clinical Research: Investigator-Sponsored Studies these must be routed through standard, independent Roche IIS channels.

• Non-Clinical Education: General professional development, business administration qualifications (e.g., MBAs), or non-healthcare-specific skills training.

• Formal Clinical Guidelines: The creation of formal treatment guidelines, which must remain under the exclusive purview of independent Medical/Scientific Societies.

• Individual Requests: Funding requests for individuals, including personal travel grants, congress attendance sponsorships, or individual fellowships outside official institutional programs.

Applications are open to legal entities, including haemophilia treatment centers, healthcare institutions and organisations, academic and research institutions, research networks and collaborative groups.

Yes. LiFE encourages scalable initiatives and collaborations that can generate broader learning or impact across healthcare systems.

Applications are reviewed based on:

• Strategic Alignment and Scientific Merit

• Expected Outcomes and Success Metrics

• Unmet Need and Differentiation 

• Feasibility, Execution, and Budget

• Project Personnel

• Additional criteria (not mandatory): Multi-Stakeholder Value, Scalability, Sustainability

Roche’s involvement depends entirely on the contracting framework of the approved initiative:

• Grants and Sponsorships: The project is executed entirely independently by the applicant. To ensure scientific integrity and autonomy, Roche does not participate in the hands-on execution or development of the project.

• Partnerships and Consortia: Roche may actively collaborate or co-create with partners on specific project deliverables, where aligned with the program's strategic objectives.

For all funded initiatives, Roche provides operational oversight to ensure funding governance, tracking of agreed milestones, and compliance reporting.

LiFE plans to operate with two proposal cycles annually, which will be posted on this website.