As sustainability is built into our business strategy, a strong commitment from all business areas and senior management is reflected in our sustainability governance structure:

• The Corporate Governance and Sustainability Committee of theBoard of Directors(BoD) is responsible and accountable for governing sustainability at the Board of Directors level. It supervises and provides advice on the sustainability strategy.

• The Corporate Executive Committee (CEC) is responsible and accountable for the overall strategy of Roche. It has delegated the responsibility for establishing, managing and coordinating the implementation of the sustainability strategy to the Corporate Sustainability Steering Committee and appoints its members.

• The Corporate Sustainability Steering Committee sets the sustainability strategy and monitors its implementation.

• The Corporate Sustainability Operations Committee is responsible for implementing and advancing our sustainability agenda, and reporting on the objectives and progress towards these objectives, across all relevant global and affiliate functions that make up our global sustainability network.

• The Global Sustainability Network contributes to the sustainability agenda, and delivers on the objectives in cross-functional and cross-divisional working groups.

Roche’s approach to sustainability reflects our decentralised model: sustainability is implemented locally, answering local needs and meeting local expectations, and is the responsibility of the local management teams.

Ultimately, sustainability is part of everyone’s job at Roche.

The Roche Corporate Sustainability Charter establishes the governance of sustainability at Roche by describing the mandate, membership and responsibilities of the Corporate Sustainability Committees.

As one of the world’s largest healthcare companies, Roche takes its obligation to meet the highest standards of business ethics and integrity very seriously. Meeting those standards is the responsibility of every employee.

Our standards of business integrity are set forth in our Code of Conduct , which include the Corporate Principles.

To further promote and support a shared understanding, Roche has implemented a number of policies, directives, position statements and guidelines that apply across the Group. Employees at all Roche sites have access to all external and internal documents either electronically (e.g. on the Roche intranet) or as hard copies.

Detailed guidance has been issued for example:

• The Behaviour in Business Directive on Integrity seeks to prevent the infringement of business integrity by addressing topics such as bribery, improper advantages, facilitation payments, gifts, entertainment, dealing with business parties and conflicts of interest.

• The Behaviour in Competition – A Guide to Competition Law helps raise awareness of how antitrust and competition laws apply to business conduct and decision-making.

• The Roche Group Insider Directive - intends to ensure professional behaviour and reinforce Roche’s reputation as a trustworthy company and reliable partner. An insider declaration must be signed by employees who have access to sensitive data or who are authorised to undertake major financial transactions.

We make every effort to inform and train all employees, and business critical contractors on the basic business standards, including providing interactive learning solutions.

The pharmaceutical industry is governed by strict regulations and guidelines for the sale and marketing of products. Our Code of Conduct addresses responsible marketing practices, setting out standards for adhering to regulatory compliance and for interacting and engaging with healthcare professionals. Roche’s interactions with healthcare professionals are aimed at exchanging scientific information intended to optimise the use of Roche’s products and services. All these interactions are based on standards of integrity and fair remuneration for services. We are committed to benchmarking our achievements against best practice; this includes transparent reporting.

Our goal is to enable healthcare professionals to make decisions independently, based on all relevant data available, in order to deliver the greatest medical benefit to patients. To help us maintain good marketing practices, we expect all Roche employees to:

• comply with applicable laws, regulations, industry codes and Roche standards

• defend Roche’s products and interests against unfair competitive practices

• seek help and advice in case of doubt

• speak up in the event of compliance concerns

We specially train staff who interact with healthcare professionals and healthcare organisations and maintain rigorous standards of risk management. In addition, Roche uses a Marketing and Sales Compliance questionnaire to help local line managers assess compliance and awareness of responsible marketing practices. Equally, all general managers must annually sign an “assurance declaration on compliance”, acknowledging compliance with these practices.

In addition, Roche uses a Marketing and Sales Compliance questionnaire to help local line managers assess compliance and awareness of responsible marketing practices. Equally, all general managers must annually sign an “assurance declaration on compliance”, acknowledging compliance with these practices.