Roche’s non-financial reporting is directed by theand assured by PricewaterhouseCoopers. The data and information collected serves as a guide for reviewing and adjusting the sustainability strategy. We firmly believe that transparent reporting helps us improve our business. We are committed to communicating relevant, clear, balanced and accurate information to our stakeholders.

We provide integrated information about Roche’s financial and non-financial performance in ouras well as in ourand cover all regions and divisions from 1 January to 31 December 2022.

The reporting scope is defined and outlined in our Finance Report and there have been no significant changes in scope in 2022 compared to 2021.

A comprehensive overview to navigate through our sustainability initiatives & reporting across the three pillars of ESG: Environment, Society and Governance.

We contribute to a number of the(SDGs) and its 169 specific targets within the sphere of our work. We are particularly pleased to see a dedicated goal on Health (SDG 3). This is important as health plays a crucial role in societal and economic development.

Roche has been ato the UN Global Compact since 2021. Ourshows our commitment to making the UNGC and its ten principles part of our strategy, culture and day-to-day operations, and to advancing the broader development goals of the United Nations, in particular the

As part of Roche's efforts to advance sustainability reporting, we support the activities of the Global Reporting Initiative (GRI) as a Community member and advocate its mission to empower decision makers worldwide, through the GRI sustainability reporting standards and its multi-stakeholder network to take action towards a more sustainable world.

Roche has been using the Global Reporting Initiative as a guide and reference point since 2005. In 2018/2019, we conducted aof key topics that are highly relevant to us and to our key stakeholders in accordance with the GRI Sustainability Reporting Standards.

GRI and the European Chemical Industry Council’s () Responsible Care Reporting Guidelines provide the framework for our reporting. Each year Roche requires all its entities to provide data and information covering economic, social and environmental indicators, which are consolidated at the group level. Specifically, the grants donations and sponsorship (GSD) data collection process is detailedIn addition, Roche recognises and follows the international standard ISO 26000 guidance on social responsibility. We track our performance against key financial and non-financial indicators, that are defined in ourand grouped under our main areas of engagement.

Our current Annual Report includes an independent assurance report on our non-financial reporting, prepared by PricewaterhouseCoopers AG.