Multiple Sclerosis

We’re committed to advancing the clinical understanding of underlying disease activity and progression for the millions of people living with multiple sclerosis (MS) worldwide.


MS is a progressive disease. While MS can present itself differently for each person, its underlying biology is similar for everyone. No matter what form of MS a person is diagnosed with, disease progression is present from the start.

MS is an immune-mediated disease of the central nervous system and the leading cause of non-traumatic disability in young adults, affecting people in the prime of their lives. Disease progression was once only associated with secondary progressive and primary progressive MS but is now recognised in relapsing remitting MS, even if a person is not experiencing relapses.


MS and disease progression can be a complicated topic to understand. As we gain a deeper understanding of disease progression and the different ways MS can present itself inside the body, we know that it’s a disease that can be managed and should be treated as early as possible.

Our ongoing research continues to advance our understanding of MS disease progression and what lies within the jungle of the brain.

There’s a symbiotic relationship between our understanding of MS and our tools for measuring it – better understanding leads to better tools, and better tools lead to a better understanding. We learn as we go, both in science and in the measurement of disease and its impact. At Roche we’re committed to advancing on both fronts.

The Roche MS Innovation Challenge

Are you an innovator with a great idea to improve MS Health?

Join theSubmit your innovative proposals to improve the early detection of disease worsening, and to enhance the monitoring and prediction of the impact of disease on people’s lives. 

We believe that innovative solutions, such as digital and fluid-derived biomarkers, deep phenotyping, MRI, and AI, will improve care for #pwMS. The selected applicants will receive funding and support to bring ideas to life, subject to the Application Policy. 

The deadline is 29 February, 2024.


MS: Battle B-neath the surface

Using martial artists as a metaphor, learn how B cells, important defenders within the immune system, play a central role in MS.

Understanding progression in MS

Watch this animation to help understand what disease progression really means in MS, its impact and how to manage it.

Living with progressive MS: Jeanne's Story

Jeanne shares her perspective on life with PPMS and the adaptions she has embraced to maintain her independence.

Living with Progressive MS: Jennifer's Story

Jennifer shares her perspective on life with PPMS and how gives back to the MS community.

Maintaining independence with progressive MS

Understanding disability progression and the importance of supporting people to live their best lives.

Delaying disease progression

Learn how the two types of inflammation in MS contributes to disease progression and how it can impact a person’s life.

Protecting the house in MS

Learn about underlying disease activity and ways to reduce future irreversible disability

The roles of B cells in MS

Recent clinical evidence suggests that B cells contribute to both the inflammatory and neurodegenerative aspects of the disease.

See all stories

More cases of Neuroscience

View detail of Neuroscience

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