Self-collection has the power to transform cervical cancer prevention

Of the many types of cancer that plague our planet, cervical cancer is one of the few that is nearly 100 percent preventable. The tools are in place to eliminate this disease that kills more than 340,000 women globally- our sisters, mothers, co-workers and friends - every year.

Despite advances in science, barriers still exist that prevent some women from being screened. Among them: limited access to testing, fear and anxiety over the exam and cultural concerns.

New Roche innovation that empowers women to collect their own sample for testing is poised to break down barriers to screening

“Most cervical cancers are occurring in women who are not going for screening or are not up to date with their screening," said Mahboobeh Safaeian, an epidemiologist who has studied the application of self-collection in cervical cancer screening for nearly 20 years and now leads clinical sciences for cervical cancer and HPV - or human papillomavirus - at Roche Diagnostics. “This empowers women by putting control into their hands. It can help revolutionise access to care.”

This innovation allows women to collect their own vaginal sample with a swab that has been clinically validated for use in combination with the HPV test. The sample is then prepared and sent by a healthcare worker to the lab for testing.

HPV can be transmitted through sexual contact, with or without intercourse, and with or without condom use. Almost all cases of cervical cancer are caused by HPV, as persistent infection with certain types of the virus can lead to cervical pre-cancer or cancer. HPV screening identifies people with the virus who are most at risk for developing cervical disease or cancer.

Studies show that this method is not only widely accepted by women, but is oftentimes preferred.1 The HPV self-collected test performance is comparable to a clinician-collected cervical sample, which some women may be uncomfortable with.2

“Half of the women who die from cervical cancer didn’t get screened,” said Ed Baker, an obstetrics and gynaecology physician who heads medical affairs for infection and immunity at Roche Diagnostics. “We can really change that. It's such a natural way to solve a big problem by getting it to the underserved population.”

“Cervical cancer can be a disease of disparities,” said Carolyn Kay, obstetrics and gynaecology physician and a medical affairs leader at Roche Diagnostics. “There are transportation issues or physical proximity to healthcare. But we also see women with a history of trauma or cultural barriers to screening, which may prevent them from being screened.”

Cervical cancer is one of the most common cancers in women worldwide. It starts in the cervix, located at the lower part of the uterus. Persistent infection of certain high-risk types of the HPV virus are known to be the primary cause of cervical cancer. Cervical cancer is one of the most successfully treatable forms of cancer, as long as it is detected early and managed effectively.3

While the COVID-19 pandemic resulted in much of the world delaying cervical cancer and other routine health screenings, it has also raised awareness as to the value of self-collection, like ones for COVID.

For women living in remote areas, the impact can be life changing.

”For women, who are the cornerstone of their families and communities and cannot take a day to travel to a clinic, travelling clinics or travelling nurses can go from village to village. Women can perform their own collection there and healthcare professionals take the specimens with them to a laboratory,” said Sebastiaan van den Broek, a member of the Roche business team that is bringing self-collection to women.

It isn’t only women with limited access to healthcare who can benefit from self-collection.

“I see this being a great option for women who have healthcare coverage but may be hesitant to get screened on a regular basis,” said Sun Austin, a Roche scientist who helped lead the work around HPV self-collection.

As a doctoral student at Johns Hopkins University, Mahboobeh and her team conducted a study of about 3,000 women who self-collected vaginal samples in Uganda. About 84 percent of the study participants adhered to the method, indicating that many women are comfortable with self collecting.

“Even if you can do two screens at two really important times of a woman’s life, you're going to prevent a lot of cervical precancers from becoming cancerous,” she said. “We can really make a difference.”

Said Sebastiaan, “At Roche we go to work every day and contribute to shaping healthcare solutions because no woman should die from cervical cancer "


  1. Nelson, E. J., Maynard, B. R., Loux, T., Fatla, J., Gordon, R., & Arnold, L. D. (2017). The acceptability of self-sampled screening for HPV DNA: a systematic review and meta-analysis. Sexually Transmitted Infections, 93, 56. 

  2. Wright TC, Jr, Denny L, Kuhn L, et al. HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer. JAMA 2000;283:81–6.

  3. Accessed June 1, 2024

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