PD-L1 works like a ‘stop sign’ inactivating T cells. Interfering with PD-L1 is one way to help prevent cancer from disabling T cells in the tumour microenvironment, where tumours grow and interact with other cells.2,3
Studies are investigating whether high amounts of PD-L1 may indicate tumours more likely to respond to immunotherapies that interfere with PD-L1.2,4
These cells, called ‘tumour-infiltrating immune cells,’ can also express PD-L1 in many types of cancer. 1,2,5-7
PD-L1 on both tumour cells and tumour-infiltrating immune cells may help prevent T cells from attacking tumour cells.2,3
Studies are evaluating whether measuring the amount of PD-L1 on both tumour cells and tumour-infiltrating immune cells may help predict how well certain medicines may work, or whether measuring the amount of PD-L1 on tumour-infiltrating immune cells alone could be sufficient to serve the same purpose.8,9
Ongoing clinical studies are examining the significance of measuring the amount of the PD-L1 on tumour cells and tumour-infiltrating immune cells across diferent types of cancers, which could help doctors determine which people are most likely to respond to cancer immunotherapy alone or who may need a combination with other medicines.
Dr. Daniel Chen explains how immunotherapy may affect the PD-L1/PD-1 pathway, enabling the body to better detect and fight cancer.
Chen DS, Mellman I. Immunity. 2013. 39:1-10
Chen DS, et al. Clin Cancer Res. 2012. 18:6580-6587
Keir ME, et al. Annu Rev Immunol. 2008. 26:677-704
Quezada SA, Peggs KS. Br J Cancer. 2013. 108:1560-1565
Data on file, Genentech
Pardoll DM. Nat Rev Cancer. 2012. 12:252-264
Sharma P, et al. Proc Natl Acad Sci USA. 2007. 104:3967-3972
Herbst RS, et al. Nature. 2014. 515:563-567
Powles T, et al. Nature. 2014. 515:558-562
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