3 FACTORS to help decide on the appropriate SARS-CoV-2 test
The outbreak of SARS-CoV-2, the virus that causes COVID-19, led to a wealth of questions on how to manage the virus. Many of these questions can be answered with the help of diagnostic tests.
There's a growing variety and availability of tests related to SARS-CoV-2. All types of tests can help healthcare providers make more accurate diagnosis, support better management of individual patients and provide better guidance to manage population risk.
Choosing the appropriate test depends on the following factors:
Factor 1
Disease stage
Diagnosing active infections and managing resolved infections require different technologies.
RT-PCR tests detect the presence of SARS-CoV-2 based on its genetic make up (RNA).
Antigen tests detect certain proteins of the SARS-CoV-2 virus.
Antibody tests measure the body's immune response to SARS-CoV-2 antigens, for instance the nucleocapsid or the spike protein. (We distinguish between qualitative (providing a yes/no result) and quantitative (measure the amount of antibodies) antibody tests.)
Depending on the technology, different samples may be collected.
Factor 2
Testing location
Different healthcare settings require different instruments and tests.
Factor 3
Testing purpose
The selection of the appropriate test also depends on the respective question one wants to answer.
Physicians and other healthcare professionals
Testing for symptomatic patients to potentially guide treatment
Managing exposed individuals and essential workers
Testing of asymptomatic individuals to contain disease spread and potentially manage outbreaks
Researchers
Understanding disease prevalence in order to advise governments, health institutions and healthcare industry
Identifying recovering patients who could potentially be serum and plasma donors for developing treatments for COVID-19
Supporting the development of vaccines through tests that measure levels of antibodies to the virus
Helping with the development of treatments for infected patients
Governments and health institutions
Identifying active or past infections to support better decision making and pandemic management
Help facilitate contact tracing and surveillance
Expand access to testing
Testing types provided by Roche
Meeting the testing needs across the healthcare continuum requires a broad SARS-CoV-2 diagnostics portfolio.