Can you spot the difference?
Non-Hodgkin lymphoma (NHL) is a type of blood cancer that starts in the white blood cells, known as lymphocytes, which are a key component of the immune system.1
There are over 60 different types of NHL,2 which can also be classified as indolent (slow growing) or aggressive (fast growing), depending on how quickly the cancer grows.1 Two of the most common types, follicular lymphoma and diffuse large B-cell lymphoma (DLBCL), are very different in how, when and where they develop and how they are managed.
What are the most common subtypes of NHL?
How do cancer cells differ between subtypes?
How quickly does the disease progress?
When are patients usually diagnosed?
What is the course of the disease?
What is the unmet clinical need?
To learn more about lymphoma subtypes, visit
- 1. Leukemia & Lymphoma Society. NHL subtypes. Available at: https://www.lls.org/lymphoma/non-hodgkin-lymphoma/diagnosis/nhl-subtypes Last accessed November 2016.
- 2. Lymphoma Research Foundation. About lymphoma. Available at: http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6299689. Last accessed: November 2016.
- 3. GLOBOCAN 2012. Estimated cancer incidence, mortality and prevalence worldwide. Available at: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Last accessed November 2016.
- 4. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood 1997;89:3909-18.
- 5. American Cancer Society. Types of non-Hodgkin lymphoma. Available at: http://www.cancer.org/cancer/non-hodgkinlymphoma/detailedguide/non-hodgkin-lymphoma-types-of-non-hodgkin-lymphoma. Last accessed November 2016.
- 6. Lymphoma Association. Diffuse large B-cell lymphoma. Available at: http://www.lymphomas.org.uk/types-lymphoma/non-hodgkin-lymphoma/diffuse-large-b-cell-lymphoma. Last accessed November 2016.
- 7. Lymphoma Research Foundation. Follicular lymphoma. Available at: http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6300155. Last accessed November 2016.
- 8. Medscape. Diffuse large cell lymphoma. Available at: http://emedicine.medscape.com/article/202969-overview. Last accessed November 2016.
- 9. Rovira J, et al. Prognosis of patients with diffuse large B cell lymphoma not reaching complete response or relapsing after frontline chemotherapy or immunochemotherapy. Ann Hematol. 2015;94:803-12.
- 10. Salles GA. Clinical features, prognosis and treatment of follicular lymphoma. Hematology Am Soc Hematol Educ Program. 2007;1:216-25.
- 11. University of Maryland Medical Center. Non-Hodgkin’s lymphoma. Available at: http://umm.edu/health/medical/reports/articles/nonhodgkins-lymphoma. Last accessed November 2016.
- 12. Maurer MJ, et al. Event-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with immunochemotherapy. J Clin Oncol. 2014;32:1066-73.
- 13. Vaidya R & Witzig TE. Prognostic factors for diffuse large B-cell lymphoma in the R(X)CHOP era. Ann Oncol. 2014;25:2124-33.
- 14. Fowler N. Role of maintenance rituximab (Rituxan) therapy in the treatment of follicular lymphoma. Pharmacy and Therapeutics. 2011;36:590-8.
- 15. Dotan E, et al. Impact of rituximab (Rituxan) on the treatment of B-cell non-hodgkin’s lymphoma. Pharmacy and Therapeutics. 2010;35:148-57.