Haemophilia A can have a large impact on quality of life in those affected and can be distressing for their caregivers. Learn more about the impact of haemophilia in infants and the importance of early diagnosis and prophylactic treatment.
Haemophilia is an inherited, serious bleeding disorder where a person’s blood does not clot properly, leading to uncontrolled bleeding, which can occur spontaneously or after trauma.
Haemophilia occurs when someone lacks or doesn’t have enough clotting factors – proteins that work together to form blood clots and help stop bleeding.
Haemophilia A, where people lack clotting factor VIII, is the most common form – affecting 900,000 people worldwide. 1,2
The diagnosis of haemophilia is usually expected before birth if:3
There is a family history of bleeding
The mother has haemophilia A or knows she is a carrier of haemophilia A
There is a family history of haemophilia
There is no family history in at least 1/3 of people newly diagnosed with haemophilia.3 Depending on the severity of the haemophilia, people get diagnosed at different times in their lives:3
diagnosis often occurs during the first year of life4
diagnosis often occurs any time before the age of 5-6 years5
diagnosis often doesn’t occur until later in life5
The most common symptoms and indicators of haemophilia to look out for in infants are:
Regular and unusual bruising
Joint or muscle swelling
Uncontrolled bleeding after trauma (usually seen after intramuscular vaccinations)6
Bleeding associated with a medical procedure e.g., circumcision7
Other common ways for infants to get diagnosed is through a genetic or blood test analysing complete blood count and clotting factor levels, as well as checking bleeding time.8
Haemophilia can have a large impact on quality of life in those affected and can be distressing for their caregivers.
This is especially true in infants, with two thirds of caregivers reporting that haemophilia has impacted their life, with many reporting lost days from work and emotional stress, because of:9,10
Frequent hospital visits
Coordinating treatment schedules in their daily life
General anxieties for their infant11
Early diagnosis and prophylactic treatment from birth helps to reduce the risk of bleeding into the brain (which can be life threatening) and may also prevent bleeds that can cause disability and long-term damage to joints and muscles.1
Treating haemophilia in infants could include:
Prophylaxis or on-demand factor replacement therapy12
This is given intravenously (administered into the veins); however, this can be a treatment burden as it may increase the risk of infection, which is why infants may not be treated in the first year of life.
Prophylaxis with non-factor substitution
This includes factor VIII mimetics
Early treatment in infants is recommended to prevent long-term complications.1 If haemophilia is left untreated throughout life, there is a risk of severe bleeding externally or internally. These bleeds can present a significant health concern as they can often lead to:
Development of partially clotted, pooled blood under the skin or around organs known as hematomas
Long-term joint damage, in some cases arthropathy4 – a type of arthritis
In worst case situations, brain bleeds and internal organ bleeds,13 that can cause death
Srivastava, A, et al. WFH Guidelines for the Management of Hemophilia, 3rd edition. Haemophilia. 2020: 26 (Suppl 6):1‐158. 3.
Iorio A, et al. Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males. Ann Intern Med. 2019;171(8):540-546.
Konkle BA, et al. GeneReviews®. In: Adam MP, et al., editors. Hemophilia A. University of Washington, Seattle; 1993-2022.
Salen, P. and Babiker HM. StatPearls. Haemophilia A. Treasure Island (FL); 2022.
Von Mackensen, S., et al. The impact of psychosocial determinants on caregivers’ burden of children with haemophilia (results of the BBC study). Haemophilia. 2019;25(3): 424-432.
Halimeh, S., et al. How Caring for Toddlers and Young Children with Severe Haemophilia Impacts on Caregiver's Burden. Blood. 2019;134(Supplement_1): 3461-3461.
Wiley RE., et al. From the voices of people with haemophilia A and their caregivers: Challenges with current treatment, their impact on quality of life and desired improvements in future therapies. Haemophilia. 2019;25(3): 433–440.
Berntorp, E., et al. Haemophilia. Nat Rev Dis Primers. 2021;7(1):45.