X-Ray Crystallography


X-Ray Crystallography provides precise information on the tridimensional structure proteins and small molecules, allowing scientists to actually “see” the shape and conformational preference of the targets of interest. The information gained through X-ray crystallography feeds into molecular modeling, giving robust reference points for the prediction of drug-protein interactions. Target proteins can be crystallized with or without an interacting substance, and the technology can give reliable information on site of binding, affinity and the conformational modifications induced by the drug, greatly reducing the empirical nature of drug design. Roche was the first pharmaceutical company to build a protein crystallography platform and has since strived to push the limits of this technology by addressing challenging problems, like membrane-bound proteins.

Tags: Chemistry