Investor Update

Basel, 23 February 2011

Xeloda approved in Japan for Additional Indication of Advanced or Recurrent Gastric Cancer, which is Not Amenable to Curative Resection

Dear Investor,
Please find attached a press release by Chugai:

http://www.roche.com/inv-update-2011-02-23-annex.pdf

Do not hesitate to contact us for any further questions.