Biomarker and Experimental Medicine Leader, Infectious Disease

Switzerland, Basel-City, Basel

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At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.
That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Job mission

In the Infectious Disease Therapeutic Area, our efforts focus on global health challenges: curing chronic hepatitis B virus infection and confronting the threats posed by respiratory viruses and antimicrobial resistance. As a member of the Infectious Disease Translational Medicine group, you will be part of an international group of scientists and clinicians who are developing antiviral, immunomodulator and antibiotic medicines for the future.

Your impact


The Biomarker and Experimental Medicine Leader:

  • Is responsible for biomarker related activities, working closely with scientists and project teams to develop biomarker plans for preclinical and clinical-stage projects 

  • Leads and acts as an individual contributor for multidisciplinary expert teams

  • Is assigned to a portfolio project at entry into portfolio as an expert guide for early biomarker deliverables with increasing responsibilities until assuming full accountability for the clinical biomarker strategy 

  • Integrates input from technical experts to develop, implement and adjust state of the art analytical concepts recognizing the scientific and clinical basis, the validation status, and the statistical issues related to proposed biomarkers

  • Is accountable for the interpretation of pre-clinical and clinical biomarker data and for ensuring accurate communications to senior leadership, governance bodies, clinical investigators, health authorities, etc. 

  • Is responsible for biomarker-specific sections in internal and external documents (incl. study protocols, regulatory, reports, manuals, etc.) 

  • Integrates pre-clinical, clinical and real-world data to develop project-specific patient-centred options, to increase the probability of clinical success 

  • Designs and leads forward and reverse translational research studies and/or projects in collaboration with internal and external partners to support the pre-clinical and clinical infectious disease portfolio including prioritization and harmonization of biomarker platforms

  • Drives scientific collaborations with external/academic partners to gain insights into disease biology and patient segmentation from biomarker analyses of clinical samples

  • Stays up to date on novel biomarker modalities and technologies

Your profile

  • You hold an MD and/or a PhD in a relevant scientific field, e.g., infectious disease, immunology, or molecular biology

  • You have a deep understanding of virus-host interactions and immunologic mechanisms underlying complex diseases

  • You have extensive experience of discovery and development of biomarkers in infectious diseases and/or immunology, acquired in a research or clinical setting

  • You have at least 3 years of post-doctoral experience in translational research including discovery, development and utilisation of biomarkers or biomarker-technologies in an academic and/or industry setting, supported by a strong publication record or equivalent contributions

  • You have previous experience of clinical studies (e.g., as biomarker study lead), including the development and execution of the biomarker plan and the successful implementation of related biomarker activities

  • You have strong abilities in data analysis and data management, preferably developed within a scientific context. Knowledge of biomedical statistics is a plus. Knowledge of regulatory, safety or biosample operations would be an advantage

  • You have expertise in generating, interpreting and communicating complex datasets to enable proof of biology and to guide dose selection and safety across clinical programs

  • You can develop and clearly articulate solutions to complex problems

  • You have excellent presentation and communication skills and are able to distil complex issues for different audiences

  • You have a strong interest in understanding and developing skills in state of the art and next-generation technologies

  • You can work as an individual contributor but are an experienced matrix leader and decision-maker with strong leadership skills to guide and motivate teams

  • You are able to prioritise work under pressure to optimise delivery

  • You have skills and experience that enable easy integration into an energetic, forward-looking, multi-cultural and inspiring global organisation

Our commitment

Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo.

Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Job Level:

Individual contributor