Roche Postdoctoral Fellow (RPF) in Investigative Safety and Immunosafety: Blood-endothelium interaction for the development and application of a Blood-on-Chip platform

Switzerland, Basel-City, Basel

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As a Postdoctoral Fellow in the Department of Pharmaceutical Sciences, you will focus on an exploratory research project developing and applying a Blood-on-Chip platform.

Pharmaceutical Sciences (PS) is a global function within Roche Pharma Research and Early Development (pRED) which covers several research areas including Immunosafety and Investigative Safety. As part of the Investigative Safety and Immunosafety group, you will work in close collaboration with scientists from different departments within PS/pRED to generate and integrate molecular, cellular, tissue, and functional data with the goal of delivering unique and holistic insights into drug safety and enable informed decisions to bring the best drugs to patients.

The position:

In this position, you will develop and apply innovative in vitro microfluidic models of the human vasculature to enhance the physiological relevance and predictive value of cytokine release assessment with the final goal of enabling a better translation of preclinical findings to the clinical setting.

This position is sponsored by the Roche Postdoctoral Fellowship Program.

The RPF Program has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world. One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals if necessary preceded by priority patent applications.

The duration of RPF project is initially set for two years, with the possibility of extension for a third year. You will be based in the Roche Campus in Basel.

More information about the RPF Programme:

Who you are:

You have a postgraduate scientific degree in the field of cell biology, hematology, immunology or related fields. We are looking for a highly motivated postdoctoral scientist who graduated in the last 3 years and has the following expertise:

  • Expertise in vitro models of the vasculature, ideally “Blood-on-Chip” type applications or blood/endothelium interaction and solid experience in applying this knowledge to answer complex biological questions
  • Experience in hematology is a big plus
  • Practical experience in primary cell culture and in vitro immunoassay (e.g. ELISA, ELISpot, multiplexed immunoassays, etc.)
  • Experience in the field of cancer immunotherapy is a plus
  • Experience with biologics, namely monoclonal antibodies, fusion/bispecific molecules, peptides, and immune-engaging molecules is a plus
  • Theoretical and practical knowledge of immunology and flow cytometry is a plus
  • Excellent interpersonal and communication skills and strong attitude to teamwork
  • Excellent strategic thinking, self-initiative, and a strong sense of accountability
  • Ability and willingness to challenge, be challenged and learn
  • Proficient in spoken and written English

You have been actively engaged in scientific research continuously since your PhD and ready to start an RPF postdoctoral activity no later than 4 years after your PhD.

Next Steps:
The start date of this fellowship is February 2022, or on availability. Please clearly indicate your preferred starting date on your motivation letter.
All applications always need to include

  • a CV, motivation letter,

  • publication list

  • if available, your PhD

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Tags: RPF

Job Level:

Entry Level