The Immunology Incubator is an innovative interface between Roche Pharma Research and Early Development (pRED) and the next generation of academic leaders. High potential, early to mid-career investigators and postdocs with an immunology background are embedded within pRED to conduct exploratory research that advances disease understanding and uncovers novel therapeutic targets.
pRED has an opening for an Immunology Incubator Postdoc Fellow within Immunology Discovery, part of the Immunology, Infections Diseases and Ophthalmology (I2O) Department, located in Basel, Switzerland.
We are seeking an independent and highly motivated researcher to advance our understanding of the mechanisms underlying the progression of inflammatory bowel diseases (IBD). Specifically, the research project will aim at investigating the role of T cell plasticity in maintaining intestinal homeostasis and in the development of chronic and tissue-damaging intestinal inflammation. In addition, the relationship between T cell plasticity and intestinal microbiota will be a central element of this project.
In this position you will:
- Develop methods for isolation of immune cells from blood and tissue
- Perform detailed immune phenotyping of cell populations of interest using multicolormulti-color flow cytometry
- Perform sophisticated in vitro 3D cultures, including organoids, of human and mouse cells
- Investigate the impact of bacterial isolates and/or metabolites on host immune, epithelial and stromal cells
- In collaboration with data scientists, analyze multi omics data sets including scRNAseq, TCRseq, 16Sseq, metabolomics and identify molecules to be tested in vitro
- Carry out in vivo studies to further mechanistic understanding
- Form close collaborative relationships with other scientists within the Immunology Incubator, I2O Department and technical teams in other functions
You have experience and expertise in the following:
- You hold a PhD in immunology obtained no longer than four years ago
- You have a profound understanding of human immunology, mucosal immunity and T cell biology.
- You have extensive experience with state-of-the-art flow cytometry, including FACS
- You have a track record of hands-on experience with isolation and cultivation of human immune cells
- Experience within vivo models of inflammation is a plus
- Experience in data analysis using R or Python is a plus
- You have very good interpersonal and communication skills, are able to build good working relationships and are an outstanding teammate
- Your experience and investigative attitude allow you to work independently, to design, perform and interpret experiments and to embark on new scientific methodologies.
- You published as a leading author in top-tier journals
- You have a strong team spirit, and you like to work in international teams
- Your excellent English skills, written and spoken, comlelte your profile
More information about the RPF Programme: https://www.roche.com/careers/workplaces/wp_research/the-roche-postdoctoral-fellowship-programme.htm