Internship for Scientific Exchange - Identification and validation of novel glial targets for PET tracer discovery - RiSE (Q2 2021, 9 months)

Switzerland, Basel-City, Basel

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At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work every single day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

The Position

The RiSE program (Roche Internships for Scientific Exchange) is a highly competitive student research program at Roche. It offers the most talented postgraduate PhD and medical degree students the opportunity to be fully integrated into our interdisciplinary and international industry R&D environment. As a RiSE student you will enhance your competencies, gain valuable work experience with us, and eventually become part of a world-wide network of RiSE Alumni.

The Neuroscience and Rare Diseases Discovery and Translational Area (NRD DTA) is developing medicines for a range of serious neurological diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autism, spinal muscular atrophy, and Huntington’s disease.

As RiSE student in the NRD DTA you will join a cross-functional team from the Imaging group in Biomarkers and Translational Technologies (BTT), the Neuroimmunology section, and Biomarkers, Bioinformatics and Omics in Pharmaceutical Sciences (PS-BiOmics). You will work at the Roche Innovation Center Basel, Switzerland, and perform research in the discovery and validation of novel PET targets for glial cells. You will be hosted and mentored by Roche scientists who will guide you through your research and provide you with the needed work infrastructure and collaborative network.

During the internship your tasks will include

  • to mine existing gene and protein expression data sets for specific markers for glial cells.

  • to select the most promising targets based on their expression profile and suggested concentration in the CNS.

  • to identify and validate available antibodies for these targets and evaluate tissue expression on post mortem brain tissue (human disease and preclinical models) by immunoassays (WB, IHC, IF, ELISA). 

  • to initiate radioligand discovery and development with expert departments.

  • to perform comparative in vitro/ex vivo autoradiography for selected targets with pre-existing radioligands.

Who You Are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

Moreover you are/have

  • Enrolled in a PhD or medical degree program at a university and are looking to expand your experience with an industry internship (must still be enrolled at university for 50% of the duration of the stay at Roche)

  • Profound knowledge in neuroscience/neuroimmunology is required. Experience in protein expression profiling and data analysis is advantageous.

  • Experience with tissue processing and immunoassays.

  • Experience in PET ligand characterization/autoradiography is considered a plus.

  • An independent and proactive working style.

Information about application documents and start date

The preferred start date of the internship is April; 2021 or upon availability.

Applications need to include a CV and a cover letter, as well as a letter from your academic supervisor supporting your application to the RiSE Program. Please note that due to regulations non-EU/EFTA citizens have to provide a certificate from the university stating that an industry internship is mandatory as part of the university training.

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