Disease Modeling Scientist, Oncology

Switzerland, Basel-City, Basel
United Kingdom, Welwyn

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At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. We also believe that good business means a better world. That is why we come to work every single day. We commit ourselves to scientific rigour, unassailable ethics and access to medical innovations for all. We do this today to build a better tomorrow.

For more than a decade, Roche has been incorporating the innovative approaches of disease modeling into drug development. Disease modeling differs from classical pharmacokinetic and pharmacodynamic modeling (PK/PD) by focusing on the quantitative aspects of the disease itself. In Oncology we have implemented these approaches across modalities with particular advances in the field of Cancer Immunotherapy. Roche is a recognized world leader in Oncology with a wide-ranging portfolio across all stages of development. The opportunity for quantitative scientists to have an impact and help design medicines for patients is huge.

We are looking for a highly motivated, numerate scientist who can join our quest to better understand the mechanisms whereby cancers grow and how we can optimise treatments against them.

Major Responsibilities And Accountabilities

  • Based on the disease area portfolio and priorities , the disease area modeling scientist is accountable for the development and the maintenance of timely and scientifically sound investigations to better understand the mechanisms of cancer growth and its inhibition
  • Will support the Disease modelling Leader in the implementation of the Disease Modeling strategy across the Oncology therapeutic area
  • Ensures formal integration of the knowledge of disease mechanisms, drug target pathways, and drug properties into mathematical models with an optimal use of data, i.e. literature, competitor, preclinical and clinical (internal or external database)
  • Collaborates effectively with internal modeling groups as well as external academic and commercial modeling groups
  • May identify opportunities for utilizing the Roche Postdoctoral Fellowship program to accomplish disease modeling objectives

You own a MD, or PharmD or PhD (in natural sciences, mathematics, physical sciences or engineering) or any combination of these. Experience in the planning and conduct of Modeling and Simulation projects (preferably in a pharmaceutical industry setting). Prior experience in Oncology would be desirable but not essential.

Experience And/or Competencies Required

  • Experienced mathematical modeler with advanced pharmacological, disease area and technical expertise
  • Strong interest in developing translational drug disease models integrating, disease mechanisms, target pathways and drug candidate properties as formal mathematical concepts
  • Hands on experience with M&S software, e.g. NONMEM, R, MATHLAB, Simulo, BUGS and Berkeley Madonna, etc., with specific programming skills
  • Good knowledge of the Drug Discovery and Development process.
  • Highly effective team work and interpersonal skills (globally, internal and externally)
  • Thinks broadly, strategically, and timely when preventing, solving or managing problems
  • Flexibility and confidence to handle ambiguities, changing demands and changing priorities
  • Ability to learn from experience – seeking feedback and modifying behavior in light of the feedback received
  • Highly effective verbal and written communication/ presentation skills

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills.

The more inclusive we are, the better our work will be.