Lab Head, Enzymology of Drug Metabolism (M/F/D)

Switzerland, Basel-City, Basel

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Pharmaceutical Sciences (PS) is a global function within Roche Pharma Research and Early Development (pRED). We enable discovery and early development of drug candidates in a rich portfolio of small molecules, large molecules, oligonucleotides and gene therapies in oncology, immunology, neuroscience, ophthalmology, rare and infectious diseases. We are currently supportingover 150 projects in the different phases of research and development.

The Investigative Safety department within PS is responsible for the conduct of all in vitro work to determine the ADME and safety of new Roche medicines. We are looking for someone to join our team who will design, interpret and communicate small molecule drug metabolism enzymology studies. 

Responsibilities

  • Plan, monitor, communicate and report enzymology studies both in a drug discovery and drug development setting and reporting to Enzymology and DDI group head.

  • Direct the laboratory work in enzymology and allied experimental areas of small molecule drug metabolism. 

  • Develop new enzyme phenotyping methodologies and approaches.

  • Identify metabolic enzymes responsible for compound dispositions, followed by estimations of fractions metabolized (fm) in alignment with project leaders and clinical pharmacologists.

Skills

  • Good knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics and experimental design.

  • Competence in HPLC and Mass Spectrometric method development, troubleshooting and data analysis.

  • Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies).

  • Knowledge of fm estimation based on enzymology, metabolite identification, clinical PK/DDI and mass balance study data according to regulatory guidance documents would be an asset.

  • Strong communication skills; ability to work in a fast-paced and quickly changing environment in close collaboration with partner functions.

  • Fluent in English, ability to communicate in German an advantage.

Education and Experience

  • PhD in chemistry, biochemistry, pharmacokinetics or equivalently relevant study area 

  • 3 years experience in pharmaceutical industry, biotech or CRO 

  • Experience with using automated liquid handling systems (e.g. Tecan Fluent) for performance of in vitro experimental work