Translational Medicine Leader Ophthalmology

Suisse, Bâle-Ville, Basel

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At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are daring in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

At Roche pRED, our purpose is to take on these tough medical challenges, follow the science and transform it into medicines with life-changing benefits for patients. This is what we proudly dedicate ourselves to everyday.

The Ophthalmology group is recruiting Translational Medicine Leaders to lead early development projects, chiefly in the ophthalmologic disorders.

In this role you will lead early stage clinical projects through proof of mechanism and proof of concept to transform molecules into new medicines in area with high unmet medical need. This includes enabling testing of biological and clinical hypothesis, including methods for establishing target engagement, Pharmaco-dynamic responses, patient selection and stratification and measuring disease progression.

The remit includes programs from late preclinical through Phase 3 and preparation for market authorization and filing. You will develop therapeutic area biomarker strategy and contribute to therapeutic strategy of Ophthalmology and Lead biomarker subteams and be a member of clinical and project teams as applicable.

You will be accountable for molecular and imaging biomarker data in trials involving, ensuring standardization of methodologies across sites and countries, highest data QC, monitoring of sites and CROs, and protocol compliance.

  • Guide diagnostic biomarker development and PHC strategy
  • Design, edit, write and review protocols and study reports for experimental medicine and clinical pharmacology studies from early proof-of-concept through global Phase III
  • Work with statisticians on analysis plans involving molecular and imaging biomarker endpoints.
  • Liaise closely with cross-functional study team members, providing expert input on data review and interpretation
  • Explore and develop novel opportunities to integrate biomarker studies into late stage development
  • Publish data in top-tier journals, attend and present at international meetings

Who you are

A MD with a board certification in Ophthalmology is required. An expertise in imaging of retinal diseases is a clear asset for the role.

In addition, a focus on the application of Ophthalmology biomarkers in clinical development and disease understanding could be a real asset and clinical research is preferred.

Your capacity to work effectively in multidisciplinary teams, proactive attitude, problem-solving capacity and ability to work independently is required.

Collaborative experience in pharmaceutical/biotechnology industry-based research, including expert knowledge of data acquisition and analysis within large-scale multi-center trials.

Strong publication record

Excellent oral and written communication skills in English are required

Are you ready to apply? We are looking a person who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

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