Roche Postdoctoral Fellowship, Ophthalmology Drug Discovery and Imaging (2 years)

Switzerland, Basel-Town, Basel

The Roche Postdoctoral Fellowship (RPF) program is aimed at supporting excellent young scientists focusing on collaborative R&D projects between Roche and international academic institutions. Both internal Roche and academic experts will mentor you, and you will have the potential to perform hands on research in both lab environments.
As a Roche Postdoctoral Fellow you will develop and apply new and emerging technologies to bolster our key efforts toward evaluation of candidates for therapy of vision-threatening eye diseases.
You will be working with a group of scientists within the Ophthalmology Discovery and Translation Area and Pharmaceutical Sciences, both within Roche Pharma Research and Early Development (pRED) in Basel, Switzerland.  pRED is focused on the clinical translation of therapeutic approaches for vision-threatening diseases, including age related macular degeneration, diabetic retinopathy, and glaucoma.
In this project you will develop organ-on-a-chip mammalian tissue models of the inner and outer retina including perfused neuronal and vascular systems.  You will also:
  • Develop new approaches for imaging diseases of the retina using tissue culture and animal models of eye disease using state-of-the-art imaging instrumentation;
  • Develop dynamic microfluidic organ-on-a-chip retinal tissue culture models to study drug safety as well as therapeutic efficacy in retinal diseases. You will specifically apply these models to study neurovascular and blood-retinal barrier dysfunction, and prevention/reversal by therapy using high resolution microscopy, including confocal microscopy and STORM imaging;
  • Apply in vivo imaging modalities, including optical coherence tomography (OCT), scanning laser ophthalmoscopy (SLO), in conjunction with molecularly-targeted imaging agents to visualize retinal degeneration and blood-retinal barrier dysfunction in animal models of retinal diseases;
  • Participate in scientific diligence to evaluate opportunities for internal/external innovation as well as presenting the laboratory’s scientific progress to internal stakeholders as well as the external academic and drug discovery community through presentations and peer-reviewed publications.