The Neuroscience discovery group is involved in research and development of novel therapies for diseases such as autism, schizophrenia, multiple sclerosis and Alzheimer’s disease. We are a state-of-the-art human genetics and genomics lab located in the Neuroscience discovery department at F.Hoffmann La-Roche, Basel, Switzerland and are hiring a Lab Specialist.
Our research centers on the study of human genetics and genomics of neuropsychiatric, neurodevelopmental and neurodegenerative diseases to identify genes and causal molecular pathways. The main goal of the lab is to identify and validate new drug targets using integrative genomic approaches. We aim to understand genetic, molecular and cellular mechanisms by which disease associated mutations (both common and rare) influence disease risk.
We study i) gene/isoform expression in post mortem human brain tissues and cell types from diseased and normal healthy subjects , ii) pharmacogenomics of drug response and iii) genotype- phenotype relationship through large scale genome sequencing and clinical phenotyping efforts. We work closely with our neuroscience colleagues to help them use this molecular information to target specific neural circuits in disease relevant model systems both in vitro and in vivo. We integrate multiple genomics data sets including RNA seq, Chipseq, single cell transcriptomics, long read transcript sequencing and whole genome sequencing to address these questions.
Conducting experiments with mouse, rat and post mortem human brain tissue specimens to optimize protocols for single cell and single nuclei RNAseq.
Preparing libraries for single cell RNAseq and long read sequencing
Analyzing data and presenting findings in team meetings