The Ophthalmology group is recruiting a Translational Medicine Leader to lead early development projects, chiefly in the ophthalmologic disorders.
In this role you will lead early stage clinical projects through proof of mechanism and proof of concept to transform molecules into new medicines in area with high unmet medical need. This includes enabling testing of biological and clinical hypothesis, including methods for establishing target engagement, Pharmaco-dynamic responses, patient selection and stratification and measuring disease progression.
The remit includes programs from late preclinical through Phase 3 and preparation for market authorization and filing. You will develop therapeutic area biomarker strategy and contribute to therapeutic strategy of Ophthalmology and Lead biomarker subteams and be a member of clinical and project teams as applicable.
You will be accountable for molecular and imaging biomarker data in trials involving blood- and Aqueous humour-based assays, ensuring standardization of methodologies across sites and countries, highest data QC, monitoring of sites and CROs, and protocol compliance.
- Guide diagnostic biomarker development and PHC strategy
- Design, edit, write and review protocols and study reports for experimental medicine and clinical pharmacology studies from early proof-of-concept through global Phase III
- Work with statisticians on analysis plans involving molecular and imaging biomarker endpoints.
- Liaise closely with cross-functional study team members, providing expert input on data review and interpretation
- Explore and develop novel opportunities to integrate biomarker studies into late stage development
- Publish data in top-tier journals, attend and present at international meetings
A MD with a board certification in Ophthalmology is required.
In addition, a focus on the application of Ophthalmology biomarkers in clinical development and disease understanding could be a real asset and clinical research is preferred.
A depth understanding and practical expertise in the development of molecular assays and data review is needed.
Your capacity to work effectively in multidisciplinary teams, proactive attitude, problem-solving capacity and ability to work independently is required.
Collaborative experience in pharmaceutical/biotechnology industry-based research, including expert knowledge of data acquisition and analysis within large-scale multi-center trials.
Strong publication record
Excellent oral and written communication skills in English are required
For questions please contact the Recruiting Team Switzerland +41 61 682 25 50.