Senior Principal Scientist - Immunology/ Inflammation

Switzerland, Basel-City, Basel

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At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

The Position

In the Immunology Therapeutic Area, we are developing cutting edge therapies to treat inflammatory diseases. As a member of the Immunology group, you will be part of an international group that includes scientists and clinicians that are developing immunologic medicines for the future.

We're currently looking for a creative and experienced scientist with strong expertise in immunology, a proven track record in managing target identification and validation in a drug discovery setting, strong leadership skills, and the proven ability to effectively lead projects in a matrix organization. You will be responsible for leading a team of scientists that brings new targets into the portfolio and advances them to clinics.


These responsibilities capture a portion of what your work will look like:

  • Lead early drug discovery projects within multidisciplinary teams up to clinical candidate generation.

  • Collaboratively design and interpret complex preclinical experimental studies for the validation and characterization of targets or therapeutic agents in the area of immune mediated inflammatory diseases. May direct and oversee experimental design and results of associates and post-doctoral scientists.

  • Champion new innovative initiatives in the Immunology Therapeutic Area including the evaluation of external opportunities

  • Act as an experienced resource in project teams, and demonstrate clear and professional verbal and written communication

  • Maintains and builds a network of external expertise and is well-connected to the drivers of new and emerging scientific innovation and technologies in this fast-progressing field.

  • People management including coaching and mentoring junior scientists

Who You Are

You’re someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. As fast learner you actively drive the quality of the requirements.


  • You possess a PhD degree in Life Sciences (cellular/ molecular biology, pharmacology, immunology), or a closely related discipline with 5-10 years of experience in the pharmaceutical industry.

  • Significant scientific accomplishments and successful collaborations documented by publications in high-impact journals 

  • Expertise in mucosal immunology a plus

  • Strong technical and theoretical background/expertise in immunology with a proven track record in good experimental design. Experience in back-translation of clinical data is a plus

  • Ability to effectively present scientific data and concepts to colleagues, teams and management is essential, as well as representing the Immunology TA by presenting at external meetings

  • Skillfully able to interact effectively with people, both internally and externally

  • You can communicate fluently in English

  • Excellent data management and record-keeping skills

Your location


Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Level:

Individual contributor