Principal Mechanical Engineer

United States of America, California, Pleasanton

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As a Principal Mechanical Engineer within the Roche Systems Technology Group, you will play a key role in architecting, designing and developing new scientific and diagnostic instruments and their sub-systems. These instruments consist of fluidic, mechatronic, pneumatic, thermal, optical and electrical sub-systems and are responsible for automating workflows such as those involved in patient sample processing, nucleic acid extraction, library preparation and DNA sequencing.

Responsibilities include defining and interpreting requirements and specifications, creating system and sub-system architecture, selecting and evaluating components and designing custom components, mechanisms, modules and sub-assemblies. Other critical functions include sub-system and system level assembly, characterization, testing and troubleshooting, as well as analyzing data, writing reports and presenting results.  You will work closely with other engineers and scientists on integration efforts and provide guidance and oversight to other team members, consultants, contractors and vendors


  • The ideal candidate shall exhibit a high degree of ingenuity and resourcefulness to help us solve problems, invent new technology and develop cutting-edge products. 

  • A Bachelor’s degree in Mechanical Engineering, or equivalent experience and/or education, with a minimum of 5 years of relevant industry experience designing, building, and/or supporting life science instrumentation or diagnostic/medical devices. Candidates with exceptional aptitude and experience from other fields or disciplines will also be considered

  • Contributed to the design or development of at least two life science or diagnostic instruments or devices

  • Experience designing systems for handling samples and reagents used in the analysis, processing or production of RNA, DNA and/or proteins

  • Experience designing and implementing complex, high performance fluidic systems utilizing custom manifolds with integrated pumps, valves, sensors, temperature control elements and other components

  • Experience designing automation systems and related mechanisms using both electric and pneumatic actuators

  • Solid understanding of physics and engineering fundamentals

  • A positive, proactive attitude and a strong passion for science, engineering and high-impact product development

  • Excellent written and verbal communication skills

  • Demonstrated success working in multidisciplinary team environments

  • Expertise in CAD for mechanical design and FEA simulations (Solidworks highly preferred)

  • Proficiency with common machine shop tools as well as test and measurement equipment

  • Proficiency with rapid prototyping technology such as 3D printers, laser cutters, CNC mills/lathes

  • Proficiency  with Python, LabVIEW or similar tools for device control and data acquisition


  • Proficiency with MATLAB and Python for analysis, modeling and simulations.

  • Proficiency with Solidworks PDM or similar document management tools

  • Experience with design control under ISO standards

  • Experience designing for high volume injection molding

  • Proficiency in GD&T

  • Understanding of chemistry, biological assays and sequencing technology

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at