Discovery Scientist Neural Circuits (one-year temporary role))

Switzerland, Basel-City, Basel

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At Roche, we believe it is urgent to deliver medical solutions now – even as we develop innovations for the future. We are passionate about improving the lives of patients with brain diseases and strive for ambitious ideas, innovative approaches, and urgent action. Our belief is that our success as a company will come from developing therapies for patients in need, which is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

Within Roche’s Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases represents a major focus area where we are committed to realizing our long-term vision of changing the lives of patients with severe brain disorders. Our preclinical research and early clinical development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementia, and multiple sclerosis. With unparalleled strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system.

To achieve our goals, Roche pRED Neuroscience & Rare Diseases (NRD) is currently undergoing a major and exciting recruitment effort for a large number of new positions. The position sits in the Systems Neuroscience Section in NRD, but you will also collaborate across the pRED organization.

The position

We are looking for a highly motivated Discovery Scientist to join our laboratories in the Systems Neuroscience Section. You will contribute to the expansion of our drug discovery efforts in the area of neurodegenerative and neurodevelopmental diseases, sleep physiology, cellular and network communication, translational circuit readouts, and in vivo neuropharmacology. Your work will help us to identify the next generation of targets and aid robust decision-making on our future therapies.

As a Discovery Scientist, your main responsibilities are:

  • Actively plan and perform data analysis on complex cellular and in vivo physiology and behavioral datasets using diverse computational approaches, with a strong emphasis on Machine Learning.

  • Support the assessment and implementation of approaches for describing the microstructure of spontaneous rodent behavior (e.g. MoSeq; CAPTURE; B-SOiD or DeepLabCut combined with other supervised or unsupervised machine learning approaches).

  • Learn representations of the individual features and of time series experimental data

  • Determine disease progression trajectories and implement classifiers on these trajectories.

  • Create visualization methods for the trajectories.

  • Lead or support research projects, working in cross-functional project teams, reporting on progress, with defined deliverables and deadlines.

  • Integrate Develop and expand data analysis workflows, and explain results to expert and non-expert audiences.

  • Develop novel ideas and explore new targets through either in-house research initiatives and/or external collaborations.

In addition, you will:

  • Demonstrate scientific excellence by publishing original research and presenting at scientific meetings.

  • Maintain laboratory records and ensure a FAIR data environment and work practices.

Who you are:

With a Ph.D., you have post-doctoral experience in neuroscience or a related field. You have a strong publication record in topics related to systems neuroscience and machine learning. Your publications in machine learning center around time series of healthcare data, preferably with a focus on tracking the development of neurological disorders using physiological, electrophysiological, and motion capture data.

You must have hands-on experience with the development of machine learning models in biological systems, for example, to demonstrate group differences or to study the effect of pharmacological or genetic challenges. A strength would be the application of these methodologies to both ex vivo and in vivo electrophysiological data sets or motion capture data from behavioral studies. Furthermore, you should show expertise in the analysis of time series data and the application of deep learning models to predict disease outcome.

You are a strong team player, and you foster a collaborative spirit with scientists and colleagues. You can adapt to a fast-paced, changing environment, are fluent in English, and have good presentation and communication skills. You are well organized and committed to formal record keeping.

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies.

Are you ready to apply? Roche embraces diversity and equal opportunity in a serious way. We are committed to building teams that represent a range of backgrounds, perspectives, and skills.

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