Student Internship, Investigating mechanisms of RNA splicing dysfunction in neurodegeneration (starting as soon as possible, 1 year)

Switzerland, Basel-City, Basel

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At Roche 94.000 People across 100 countries are pushing back the frontiers of healthcare. Working together, we have become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. We believe it is urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are brave in both decision and action, we believe that good business means a better world.

That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

The project is aimed at establishing models and functional assays to investigate RNA splicing dysfunction in neurodegeneration.

Your main accountabilities will be

  • Support developing innovative cellular models based on human pluripotent stem cell (hiPSC)-derived neurons and brain organoids

  • The application of molecular, biochemical and imaging approaches to understand disease-related molecular processes and their contribution to disease phenotypes

  • Investigating and validating novel molecular mechanisms implicated in Frontototemporal lobar degeneration (FTLD), Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD)


Who you are

You are someone who wants to influence your own development. You are looking for a company where you have the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. As fast learner, you actively drive the quality of the requirements.



Moreover, you are

  • An ambitious student who is currently enrolled in life-sciences (preferably in the area of cellular or molecular Biology, Biochemistry or Neuroscience) or in a gap year between degrees

  • Advanced in understanding of neurodegeneration principles

  • Preferably experienced in 1) mammalian cell culture, in particular with hiPSC/hESC maintenance and differentiation 2) gene expression analysis (qPCR/RNA-Seq) 3) Immunohistochemistry, Immunocytochemistry and confocal microscopy 4) Experience in brain organoid generation is a strong plus

If you are proud of contributing and feel you have the dedication to teamwork and innovation that we are seeking, then Roche is the organization for you. Every role at Roche plays a part in making a difference to patients’ lives. If you want to work in a passionate team, make your mark & improve lives, please apply now.

We are offering an internship position starting as soon as possible for 12 months. Please indicate the desired duration of the internship on your motivation letter. Applications need to include a CV and a motivation letter both merged in one document.

Due to regulations UK, non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory as part of the application documents.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

More information about career start at Roche you can find <a href="https://www.roche.com/careers/our-locations/europe/switzerland/ch-your-job/students_and_graduates.htm?utm_source=genextjobsearch&utm_medium=jobad&utm_campaign=genextjobad&utm_content=eicjobdescription">here</a><br />

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