Laboratory Technician/Associate for Oligonucleotide synthesis and formulation (Fixed-term contract)

Denmark, Capital, Copenhagen

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We seek a highly skilled and motivated Associate/Laboratory Technician with solid laboratory skills as well as strong collaborative skills for temporary position in the Synthesis and Optimization Department at Roche Innovation Center Copenhagen (RICC) in Denmark until the end of April 2022.

Background

The Therapeutics Modality organization (TMo) in Roches division for pharma Research and Early Development’s (pRED) is a community of over 750 scientists designing and developing next generation therapeutics. We work in close collaboration with our Disease Therapeutic Area (DTA), Pharmaceutical Sciences and Pharma Technical Development partners to bring innovative medicines to patients. The RNA Molecule Research (RMR) organization is part of the TMo family and comprises capabilities for the discovery, optimization, and synthesis of nucleic acid based therapeutics.

Predominantly based at DTU campus in Hørsholm, Denmark, the Roche Innovation Center Copenhagen (RICC) is a leader in the field of nucleic acid based therapeutics. At RICC we utilize and develop the potential of the emerging technology to meet medical needs for patients.

RICC is organized into three main Departments:  RMR Discovery, RMR Synthesis and Optimization and RMR Projects, Program and Strategy. In RMR, we work in a highly collaborative, open and engaging environment where we continuously strive to push the boundaries for innovation and development.

In Synthesis and Optimization, we synthesize innovative APIs and provide formulations to supply and enable all preclinical activities paving the way towards Clinical Candidate Selection. We are RMRs chemistry experts and together with our Discovery function partners, we work to generate scientific and technical knowledge to discover novel molecules with diverse modes of action for unmet medical needs across disease therapeutic areas. We build our strength on a broad diversity of hardworking technical experts and chemists delivering and innovating in the space of RNA-based therapeutics.

The department consists of scientists and associates collaborating to develop and optimize oligonucleotide based chemistries. We are working with automated solid phase synthesis and automated downstream processes for purification of the molecules utilizing methods optimized for the specific scale and compound design. We have an explorative and open mindset to always optimize current chemistry technologies and processes as well as developing new technologies to develop promising oligonucleotide drug candidates.

This is a unique opportunity to join our team at the Roche Innovation Center Copenhagen.

Job description

We are seeking a colleague with a strong technical profile to join the synthesis team. The team covers tasks ranging from synthesis of oligonucleotides in small amounts in a High Throughput automated workflow to the synthesis of compounds in mg to g scale.The team is responsible for synthesis, purification and QC of the compounds as well as formulation and preparations of shipments.

You will find yourself in a dynamic matrix structure with changing tasks and you will be working in close collaboration with Project Leaders, Scientists and Associates in an agile organization.


 

Your profile

You have an education as a Laboratory Technician (Laborant) or a related discipline and at least 5 years of hands-on laboratory experience from a chemistry laboratory.

In addition, you bring many of the following skills and competences:

  • Experience with HPLC/UPLC – both analytical and preparative using multiple techniques such as RP, ion exchange and size-exclusion

  • Experience with solid phase synthesis and/or automations

  • Experience with Äkta instruments from GE Healthcare

  • Strong technical skill and able to resolve technical issues with the equipment you use 

  • Innovative and positive mindset, with a motivation for problem solving and for generation of high quality data packages

  • Personal drive, engagement and a ”can-do” spirit

  • Thriving in a constantly changing environment

  • Motivated by shared as well as individual goals and meeting deadlines

  • Ability to work independently and focused, while also having strong collaborative skills

  • Written and verbal fluency in English is required

Your application

 Please submit your application by clicking on the application link no later than August 16 2020. The application must include

  • Application (motivated cover letter) addressing where you stand in qualifications mentioned

  • CV 

If you have additional questions, you can contact Michael Meldgaard (Michael.meldgaard@roche.com), Oligo Synthesis team leader.

Michael will be on holiday until beginning of August and will reply after that. Please do not send your application to his email address.

We will review the applications continuously and close the recruitment process once we have found the right candidate, so we encourage you to apply it as soon as possible.

Roche is an equal opportunity employer. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. 

Roche is an equal opportunity employer.

Research & Development, Research & Development > Research