Roche Postdoctoral Fellow (RPF)– Discovering novel mechanisms of ASO intracellular trafficking and endosomal escape (2 years, starting as soon as possible)

Switzerland, Basel-City, Basel

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Who we are

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both making decisions and taking action. And we believe that good business means a better world.

That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

We are seeking an independent motivated postdoctoral fellow to work on the interface of functional genomics and cellular imaging to elucidate the complex mechanism of anti-sense oligonucleotide (ASO) trafficking. The position will be shared between laboratories of Lead Discovery of Therapeutic Modalities and Pharmaceutical Sciences of Roche pRED in collaboration with an academic mentor. This position will leverage our joint expertise in quantitative microscopy and genetic screening using CRISPR/Cas9 technology to advance our drug discovery efforts in the area of ASO biology.

In this position, you will

  • Investigate new mechanisms of ASO intracellular transport
  • Identify ways to improve efficient ASO release from endosomes
  • Employ functional genetic screenings to find pathways that affect ASO trafficking and activity
  • Contribute to the understanding on how ASOs work in cells utilizing state-of-the-art imaging, molecular, cellular, proteomic, genomic, biochemical and bioinformatics technologies available within Roche Pharma Research & Early Development (pRED) and the academic mentor
  • Expected to generate results for high quality publications in peer reviewed journals

This position is sponsored by the Roche Postdoctoral Fellowship Program. The RPF Program has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world. One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals, if necessary preceded by priority patent applications.

The duration of RPF project is initially set for two years, with the possibility of extension for a third year. You will be based in (RIC Basel) with stays at our academic partner.

Who you are

You have a PhD in cell biology with a strong interest in membrane trafficking and advanced microscopy.

Moreover, you are/have

  • Expert knowledge of advanced microscopy techniques (e.g. lattice light-sheet, TIRF, super resolution) and image analysis workflows
  • Strong hands-on experience in cellular and molecular biology, preferably on mechanisms of endocytosis.
  • Hands-on-experience in fluorescence-activated cell sorting
  • Basic understanding of genetic screenings using CRISPR/Cas9 technology
  • Experience in studying nucleic acid-protein interactions, RNA biology, and antisense technology is desired
  • At least one first author published or accepted in a peer-reviewed journal
  • High-level of organization
  • Effective verbal and written communication skills

To be considered, please send us your complete application merged into one PDF including

  • CV
  • Motivation Letter (including desired starting date)

Roche embraces diversity and equal opportunity in a serious way. We are dedicated to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on http://careers.roche.ch/faq

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