Disease Modeling Expert/ Leader in Neuroscience and Rare Disease

Schweiz, Basel-Stadt, Basel

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At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

For more than a decade Roche has been incorporating the innovative approaches of disease modeling into drug development. Disease modeling differs from classical pharmacokinetic and pharmacodynamic modeling (PK/PD) by focusing on the quantitative aspects of the disease itself.

Such models may be mechanistic, data-driven or both.  The former focus on characterizing the pathophysiological mechanisms of disease, their relationship to clinical endpoints, biomarkers and patient phenotypes. Data driven models typically quantify the dynamics of disease progression, identifying patient-specific variables that discriminate slow from fast progressors and other aspects of interpatient-variability.  

By incorporating drug targets and drug properties (PK PD) into disease models one may simulate the dose- and time-dependent effects of a given drug or drug combination on the relevant clinical endpoints and biomarkers, and in different patient subgroups.

In these ways disease modeling at Roche makes key contributions to our understanding of disease biology, and to the design and analysis of clinical trials.

Major Responsibilities and Accountabilities

  • Based on the disease area portfolio and priorities , the disease area modeling leader (DTA ML) is accountable for the development and the maintenance of a timely, scientifically sound, innovative and business-oriented DTA disease modeling portfolio
  • Accountable to support the implementation of the Disease Modeling strategy
  • Ensures formal integration of the knowledge of disease mechanisms, drug target pathways, and drug properties into mathematical models with an optimal use of data, i.e. literature, competitor, preclinical and clinical (internal or external database)
  • Collaborate effectively with internal modeling groups as well as external academic and commercial modeling groups
  • Responsible for leveraging and building networks within and outside Roche to support meaningful disease modeling activities, including relationships with key opinion leaders in disease areas and/or relevant modeling methodologies
  • Identifies opportunities for utilizing the Roche Postdoctoral Fellowship program to accomplish disease modeling objectives

Qualifications:

You own a MD, or PharmD or PhD (in natural sciences, mathematics, physical sciences or engineering) or any combination of these. At least 5 years of experience in the planning and conduct of Modeling and Simulation projects (preferably in a pharmaceutical industry setting). At least 3 years of experience in the relevant disease area setting.

Experience and/or Competencies Required

  • Experienced mathematical modeler with advanced pharmacological, disease area and technical expertise
  • Strong interest in developing translational drug disease models integrating, disease mechanisms, target pathways and drug candidate properties as formal mathematical concepts
  • Hands on experience with M&S software, e.g. NONMEM, R, MATLAB, Simulo, BUGS and Berkeley Madonna, etc., with specific programming skills
  • Good knowledge of the Drug Discovery and Development process.
  • Demonstrated successful leadership in a project or matrix environment, preferably in the pharmaceutical industry
  • Effective leadership skills including mentorship, motivation, delegation and conflict management
  • Highly effective team work and interpersonal skills (globally, internal and externally)
  • Ability to explain complex M&S concepts and their impact on drug development program to non-modeler colleagues
  • Ability to establish and maintain effective working relationships with a broad range of other professionals, including key opinion leaders from academia, from different cultural backgrounds
  • Thinks broadly, strategically, and timely when preventing, solving or managing problems
  • Flexibility and confidence to handle ambiguities, changing demands and changing priorities
  • Ability to learn from experience – seeking feedback and modifying behavior in light of the feedback received
  • Highly effective verbal and written communication/ presentation skills

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills.

The more inclusive we are, the better our work will be.

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Research & Development, Research & Development > Modelling & Simulation