In the area of oncology, tissue based examinations are a key method to determine diagnosis and provide information on the progression of a disease and to predict potential response to treatment.
Besides histopathological diagnosis of the cancer tissue, molecular markers of the tumour are used to define the behaviour and prognosis of a malignancy.
Approximately 20% of all breast cancers have too much of the Her2/neu protein on their cell surface. These cancers not only tend to grow faster, but also spread more aggressively (metastasis) than other breast cancers. Tests like IHC or FISH / SISH help to detect this type of cancer.