Rheumatoid arthritis particularly affects the small joints of the hands and feet The knuckle joint shown here is inflamed and swollen, and the range of movement and strength of the joint are greatly reduced compared with a healthy joint The disease process starts with inflammation of the lining of the joint - the synovium - and is followed by destruction of the underlying cartilage, and then the bone itself The cycle of inflammation. B cells communicate via cytokines with other inflammatory cells, such as T cells and macrophages, to maintain and amplify the cycle of inflammation Rituximab binds specifically to a cell-surface marker known as CD20, found on developing B cells and mature B cells, but not on stem cells or plasma cells. When rituximab binds to CD20, it triggers mechanisms that result in targeting this select B cell population
Rituximab targets B cells RA patient during an interview with a journalist Werner Zolg during an interview with journalists Randall Stevens and Guido Magni conversing with Katja Prowald Anthony Manning during an interview with a journalist
Urs Schleuniger during an interview with a journalist Randall Stevens during an interview with a journalist Anthony Manning during his speech at the media briefing RA patient conversing with Marc Feldmann Randall Stevens during his speech at the media briefing
Impression of the media briefing Werner Zolg during his speech at the media briefing Impression of the media briefing Marc Feldmann during his speech at the media briefing Impression of the media briefing
Urs Schleuniger during his speech at the media briefing