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{\pard\sa900\fs50\f0\i Media Release\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Basel, 3 February 2010\par}
{\pard\f0\sl360\fs22\b Strong operating performance for Roche in 2009\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Record sales, double-digit growth in operating profit and Core Earnings per share \u8211? Dividend increase by 20% to 6.00 Swiss francs proposed\par}
{\pard\f0\sl360\fs22\b Group\par}
{\pard\f0\li440\ri0\sl360\fs22 - Group sales increase by 10% to 49.1 billion Swiss francs (8% in Swiss francs, 7% in US dollars). Both divisions gain market share. \par}
{\pard\f0\li440\ri0\sl360\fs22 - Operating profit before exceptional items increases by 14% (8% in Swiss francs) to 15.0 billion Swiss francs due to strong sales growth and continuing productivity improvements; at the same time investments in research and development increase by 12% to 9.9 billion Swiss francs.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Net income of 8.5 billion Swiss francs, down by 22% compared with the previous year due to exceptional items relating to the Genentech transaction and integration.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Excluding exceptional items, the Genentech transaction is already contributing to income: income attributable to Roche shareholders increases by 9% to 9.8 billion Swiss francs.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Core EPS at constant exchange rates 20% above 2008 (10% in Swiss francs).\par}\line 
{\pard
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\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl % change \cell
\pard\intbl % change \cell
\pard\intbl As % of sales \cell
\pard\intbl As % of sales \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl  \cell
\pard\intbl {\b 2009}  \cell
\pard\intbl {\b 2008}  \cell
\pard\intbl {\b In CHF}  \cell
\pard\intbl {\b In LC} {\b {\super 1} }  \cell
\pard\intbl {\b 2009}  \cell
\pard\intbl {\b 2008}  \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Sales \cell
\pard\intbl 49,051 \cell
\pard\intbl 45,617 \cell
\pard\intbl +8 \cell
\pard\intbl +10 \cell
\pard\intbl 100 \cell
\pard\intbl 100 \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Research and development \cell
\pard\intbl 9,874 \cell
\pard\intbl 8,845 \cell
\pard\intbl +12 \cell
\pard\intbl +12 \cell
\pard\intbl 20.1 \cell
\pard\intbl 19.4 \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Operating profit before exceptional items \cell
\pard\intbl 15,012 \cell
\pard\intbl 13,896 \cell
\pard\intbl +8 \cell
\pard\intbl +14 \cell
\pard\intbl 30.6 \cell
\pard\intbl 30.5 \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Operating free cash flow \cell
\pard\intbl 15,722 \cell
\pard\intbl 12,378 \cell
\pard\intbl +27 \cell
\pard\intbl +34 \cell
\pard\intbl 32.1 \cell
\pard\intbl 27.1 \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Net income attributable to Roche shareholders{\super 3}  \cell
\pard\intbl 9,798 \cell
\pard\intbl 9,001 \cell
\pard\intbl +9 \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Net income \cell
\pard\intbl 8,510 \cell
\pard\intbl 10,844 \cell
\pard\intbl -22 \cell
\pard\intbl  \cell
\pard\intbl 17.3 \cell
\pard\intbl 23.8 \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Core Earnings per share (CHF) \cell
\pard\intbl 12.19 \cell
\pard\intbl 11.04 \cell
\pard\intbl +10 \cell
\pard\intbl +20 \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1371\cellx2742\cellx4113\cellx5484\cellx6855\cellx8226\cellx9597
\pard\intbl Dividend per share{\super 2 } (CHF) \cell
\pard\intbl 6 \cell
\pard\intbl 5 \cell
\pard\intbl +20 \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs18 1 LC= local currencies\line 2 Proposed by the Board of Directors.\line 3 before exceptional items\par}
{\pard\f0\sl360\fs22\b Pharmaceuticals\par}
{\pard\f0\li440\ri0\sl360\fs22 - Pharma sales grow by 11% (8% in Swiss francs and in US dollars), almost twice the global market growth rate despite planned reductions in wholesaler inventory levels in the fourth quarter. The growth is driven by leading cancer medications and Tamiflu (influenza medicine) as well as Lucentis (ophthalmology medicine).\par}
{\pard\f0\li440\ri0\sl360\fs22 - 2010 starting with strong sales growth.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Operating profit margin before exceptional items increases 1.2 percentage points at constant exchange rates (+0.2 percentage points in Swiss francs).\par}
{\pard\f0\li440\ri0\sl360\fs22 - Strong R&D pipeline with 10 new molecular entities in late-stage clinical testing; 6 new compounds entered late-stage development in 2009.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Actemra approved in US for treatment of rheumatoid arthritis in January 2010.\par}\line 
{\pard\f0\sl360\fs22\b Diagnostics\par}
{\pard\f0\li440\ri0\sl360\fs22 - Sales increase by 9% (4% in Swiss francs and in US dollars) to 10.1 billion Swiss francs, more than twice the market growth rate.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Operating profit margin at constant exchange rates increases 0.4 percentage points (-0.4 percentage points in Swiss francs).\par}\line 
{\pard\f0\sl360\fs22\b Outlook\par}
{\pard\f0\li440\ri0\sl360\fs22 - Full-year 2010 sales for Pharmaceuticals and the Group expected to grow in the mid-single-digit range* \par}
{\pard\f0\li440\ri0\sl360\fs22 - Expected decrease of Tamiflu sales from 3.2 to 1.2 billion Swiss francs.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Sales increase of Diagnostics well ahead of market.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Planned research and development expenses will decline slightly in 2010 compared to 2009.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Roche confirms target of double-digit Core Earnings per Share growth** in 2010.\par}
{\pard\f0\li440\ri0\sl360\fs22 - Based on the strong operating free cash flow, Roche expects to reduce debt progressively and to return to a net cash position by 2015 while maintaining its attractive dividend policy.\par}\line 
{\pard\f0\li0\ri0\sa360\sl360\fs18 Barring unforeseen events.\line Unless otherwise stated, all growth rates are in local currencies.\line * Without Tamiflu sales\line ** at constant exchange rates\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Severin Schwan, CEO of Roche, on the Group\u8217?s 2009 results: \u8220?In a turbulent external environment Roche performed extraordinarily well. Sales by both Pharma and Diagnostics grew twice as fast as their respective markets. Core Earnings per share grew even more strongly than sales. And we have layed the foundation for future growth: Our Pharma pipeline now comprises 10 new molecular entities in late-stage development - which is remarkable by any standards in our industry.\u8221? Speaking of the Genentech integration, Schwan said: "Bringing Genentech fully into the Roche Group is a major step on the road to creating a stronger, even more innovative organisation."\par}
{\pard\f0\sl360\fs22\b Roche Group \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Strong sales and trading results\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Total sales grew by 10% in local currencies (8% in Swiss francs; 7% in US dollars) to 49.1 billion Swiss francs, with the Pharmaceuticals Division accounting for 80% of Group sales and the Diagnostics Division contributing 20%. Sales growth in both divisions exceeded market growth. Sales by the Pharmaceuticals Division increased 11% in local currencies (8% in Swiss francs and in US dollars) to 39.0 billion Swiss francs or almost double the global market growth rate.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Demand for the Group\u8217?s cancer medicines Avastin, Herceptin, MabThera/Rituxan, Tarceva and Xeloda continued to grow strongly. Additional major growth drivers in the Pharmaceuticals Division were Tamiflu in virology and Lucentis in ophthalmology. The Diagnostics Division achieved sales growth of 9% in local currencies (4% in Swiss francs and US dollars) to 10.1 billion Swiss francs, thereby strengthening the divisions leading market share of around 20%.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The Group\u8217?s operating profit before exceptional items increased by 14% in local currencies (8% in Swiss francs) to 15.0 billion Swiss francs. Operating profit in local currencies grew 15% to 14.2 billion Swiss francs before exceptional items in the Pharmaceuticals Division and 12% to 1.2 billion Swiss francs in the Diagnostics Division.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 At constant exchange rates, the Group\u8217?s operating profit margin before exceptional items increased 1.0 percentage points, with the Pharmaceuticals Division improving 1.2 percentage points and the Diagnostics Division 0.4 percentage points. Due to a particularly unfavourable combination of exchange rate movements, however, the Group\u8217?s operating profit margin before exceptional items in Swiss francs increased only slightly, by 0.1 percentage points to 30.6%, with the Pharmaceuticals Division improving 0.2 percentage points to 36.3% and the Diagnostics Division decreasing 0.4 percentage points to 11.9%.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The Group\u8217?s operating free cash flow increased strongly, rising 34% in local currencies (27% in Swiss francs) to 15.7 billion Swiss francs. The Group\u8217?s free cash flow remained strong in 2009, increasing by 3.9 billion Swiss francs to 8.9 billion Swiss francs. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Core EPS, which excludes exceptional items, amortisation and impairment of intangible assets, increased 20% in local currencies (10% in Swiss francs).\par}
{\pard\f0\sl360\fs22\b Significant impact of Genentech integration and changes in Group organisation\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Effective 26 March 2009, the Group obtained full ownership of Genentech. Subsequently, the Group commenced a restructuring of its US Pharmaceuticals business as well as a number of global functions. During 2009 restructuring and integration costs of 2.4 billion Swiss francs were incurred, mainly in connection with the discontinuation of a construction project at the manufacturing site at Vacaville, California, termination costs for the closure of manufacturing operations at Nutley, New Jersey, the closure of the research and development site at Palo Alto, California, and costs associated with the consolidation of the US administrative functions in South San Francisco. Approximately 1.8 billion Swiss francs of these exceptional operating expenses are non-cash items related mainly to impairments of manufacturing assets.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The Group financed the Genentech transaction by a combination of the Group\u8217?s own funds, bonds, notes and commercial paper. The Group raised net proceeds of 48.2 billion Swiss francs through a series of bond and note offerings. As a consequence, interest expenses increased substantially in 2009, and financing costs exceeded financial income by 1.7 billion Swiss francs. By the end of 2009, the Group had already repaid debt of 6.9 billion Swiss francs.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Compared to 2008, net income decreased by 22% to 8.5 billion Swiss francs, primarily due to the exceptional items. Net income attributable to Roche shareholders declined 13% to 7.8 billion francs. Excluding exceptional items, net income was down 3% and net income attributable to Roche shareholders was 9% higher compared to 2008.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The net debt position of the Group is 23.9 billion Swiss francs, a movement of 40.6 billion Swiss francs from a net cash position of 16.7 billion Swiss francs on 31 December 2008 due to the 52.7 billion Swiss francs used in the Genentech transaction. \par}
{\pard\f0\sl360\fs22\b Outlook\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Barring unforeseen events, Roche expects sales in 2010 for the Pharmaceuticals Division and for the Group to increase in the mid-single-digit range in local currencies (excluding Tamiflu). In the Diagnostics Division, we expect full-year sales to grow significantly ahead of the market. Despite an anticipated decrease in Tamiflu sales from 3.2 to 1.2 billion Swiss Francs we are aiming to achieve double-digit Core Earnings per Share growth at constant exchange rates. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Roche expects research and development expenditures to decline slightly in 2010. However, the Group\u8217?s focus remains firmly on innovation, and it will continue to invest to support its rich pharmaceuticals development pipeline, which currently comprises 10 new molecular entities and 30 additional indications for existing products in late-stage development. Over the next 12-18 months the Pharmaceuticals Division expects to file marketing applications for several major line extensions of our key cancer medicines including Avastin, MabThera/Rituxan and Xeloda, as well as for taspoglutide for type 2 diabetes.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 We expect to repay 25% of the debt raised to finance the Genentech transaction by the end of 2010. By 2011 the Group aims to achieve pre-tax annual synergies of approximately 1 billion Swiss francs. Based on the Group\u8217?s strong operating free cash flow, we expect to reduce debt progressively and to return to a net cash position by 2015. We will simultaneously maintain our attractive dividend policy.\par}
{\pard\f0\sl360\fs22\b Proposals to the Annual General Meeting 2010\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The Board of Directors will be proposing to the Annual General Meeting of Shareholders that the dividend for 2009 be increased by 20% to 6.00 Swiss francs per share and non-voting equity (up from 5.00 Swiss francs in 2008). Subject to the meeting giving its approval, this will be Roche\u8217?s 23rd consecutive annual dividend increase. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Prof. Horst Teltschik and Peter Brabeck will not be standing for re-election to the Board of Directors. As already announced, the Board of Directors will be proposing that Arthur D. Levinson, Chairman of the Board of Directors of Genentech, and William M. Burns, a member of Roche\u8217?s Corporate Executive Committee until the end of 2009, be elected as new members. Current Board members DeAnne Julius and Beatrice Weder di Mauro will be standing for a further period of office.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 {\b Division Pharmaceuticals} \par}
{\pard
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\pard\intbl  \cell
\pard\intbl In millions of CHF \cell
\pard\intbl % change in CHF \cell
\pard\intbl % change in local currencies \cell
\pard\intbl % of sales \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Sales \cell
\pard\intbl 38,996 \cell
\pard\intbl 8 \cell
\pard\intbl 11 \cell
\pard\intbl 100 \cell
\row
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\pard\intbl \u8211? United States  \cell
\pard\intbl 14,805 \cell
\pard\intbl 6 \cell
\pard\intbl 5 \cell
\pard\intbl 38 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? Western Europe  \cell
\pard\intbl 10,827 \cell
\pard\intbl 5 \cell
\pard\intbl 12 \cell
\pard\intbl 28 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? Japan \cell
\pard\intbl 4,765 \cell
\pard\intbl 43 \cell
\pard\intbl 29 \cell
\pard\intbl 12 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? International* \cell
\pard\intbl 8,599 \cell
\pard\intbl 4 \cell
\pard\intbl 13 \cell
\pard\intbl 22 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Operating profit before exceptional items \cell
\pard\intbl 14,154 \cell
\pard\intbl 9 \cell
\pard\intbl 15 \cell
\pard\intbl 36.3 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Operating free cash flow \cell
\pard\intbl 14,923 \cell
\pard\intbl 24 \cell
\pard\intbl 30 \cell
\pard\intbl 38.3 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Research and development \cell
\pard\intbl 8,896 \cell
\pard\intbl 13 \cell
\pard\intbl 13 \cell
\pard\intbl 22.8 \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs18 *Asia\u8211?Pacific, CEMAI, Latin America, Canada, Others\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales by the Pharmaceuticals Division rose 11% in local currencies (8% in Swiss francs and in US dollars) to 39.0 billion Swiss francs, or almost double the global pharmaceuticals market growth rate (6%). The world-wide spread of the pandemic A (H1N1) 2009 influenza virus led to very strong demand for Tamiflu from the second quarter on. Overall, Tamiflu contributed 2.6 billion francs, or 7 percentage points, to full-year Pharmaceuticals sales growth. Excluding Tamiflu, the division\u8217?s sales increased 4%, driven by demand for key products, including Avastin, Herceptin, MabThera/Rituxan, Lucentis, Mircera, Tarceva, Activase/TNKase and Actemra/RoActemra. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Year-on-year sales growth in the fourth quarter (8%) was heavily impacted by planned reductions in wholesaler inventory levels in several major markets. These resulted in part from a comprehensive review of distribution channel exposure. In addition, the harmonisation of distribution systems in the US following the merger of Genentech and Roche triggered a re-view of wholesaler inventory policy and subsequent destocking. The adjustment of inventory levels has been completed before the end of 2009.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 All regions contributed to the division\u8217?s strong sales growth. In the United States, growth of key oncology products, Tamiflu and Lucentis more than compensated for lower sales of CellCept and Boniva and the voluntary withdrawal of Raptiva. Sales in Western Europe were driven by demand for Tamiflu, Avastin, MabThera and Mircera, which more than offset declining sales of NeoRecormon. Sales by Chugai in Japan increased strongly due to demand for Tamiflu, key cancer medicines and Actemra. Sales in the International region (Asia\u8211?Pacific, CEMAI, Latin America, Canada, Others) were driven by demand for Tamiflu, key cancer medicines and Pegasys.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 In 2009 the Pharmaceuticals Division\u8217?s operating profit before exceptional items advanced significantly faster than sales, rising 15% in local currencies (9% in Swiss francs) to 14.2 billion francs. This strong increase was driven mainly by the performance of our key pharmaceutical products and ongoing measures to improve efficiency. The operating profit margin increased 1.2 percentage points in local currencies (+ 0.2 percentage points in Swiss francs) to 36.3% despite increased investments for new product launches and in research and development. The significant increase in R&D costs, up 13% to 8.9 billion francs, reflects investment in the division\u8217?s strong late-stage pipeline, including promising compounds such as dalcetrapib, taspoglutide, pertuzumab and T-DM1. The rise in R&D expenses was also driven by higher impairments of intangible assets. At 302 million francs, these were 203 million francs higher than in 2008, due primarily to the termination of a number of projects following a comprehensive review of the combined Roche and Genentech portfolio.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The division continued to generate a strong cash flow in 2009. Operating free cash flow increased 30% in local currencies (24% in Swiss francs) to 14.9 billion Swiss francs, driven by the strong operating performance. Continuous cost management and cash-flow generation are key priorities at Roche. This is reflected in ongoing global initiatives to increase operational efficiency and productivity in areas such as information technology, manufacturing and administration. Further stimulus is now being provided by the Genentech integration, which involved a major reorganisation not only of US pharmaceutical operations but also of the division\u8217?s global functions. Synergies are already being generated as a result of the consolidation in South San Francisco of administrative functions for the combined US organisation, the closure of the Palo Alto site, and the reshaping of global manufacturing operations. We aim to achieve pre-tax annual synergies of approximately 1 billion Swiss francs by 2011.\par}
{\pard
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl  \cell
\pard\intbl Total \cell
\pard\intbl  \cell
\pard\intbl US \cell
\pard\intbl  \cell
\pard\intbl Western Europe \cell
\pard\intbl  \cell
\pard\intbl Japan \cell
\pard\intbl  \cell
\pard\intbl International \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
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\pard\intbl CHF m \cell
\pard\intbl % \cell
\pard\intbl CHF m \cell
\pard\intbl % \cell
\pard\intbl CHF m \cell
\pard\intbl % \cell
\pard\intbl CHF m \cell
\pard\intbl % \cell
\pard\intbl CHF m \cell
\pard\intbl % \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Avastin \cell
\pard\intbl 6,222 \cell
\pard\intbl 21% \cell
\pard\intbl 3,315 \cell
\pard\intbl 14% \cell
\pard\intbl 1,790 \cell
\pard\intbl 24% \cell
\pard\intbl 404 \cell
\pard\intbl 74% \cell
\pard\intbl 713 \cell
\pard\intbl 35% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl MabThera/ Rituxan \cell
\pard\intbl 6,087 \cell
\pard\intbl 6% \cell
\pard\intbl 3,015 \cell
\pard\intbl 3% \cell
\pard\intbl 1,643 \cell
\pard\intbl 10% \cell
\pard\intbl 244 \cell
\pard\intbl 3% \cell
\pard\intbl 1,185 \cell
\pard\intbl 8% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Herceptin \cell
\pard\intbl 5,266 \cell
\pard\intbl 8% \cell
\pard\intbl 1,566 \cell
\pard\intbl 4% \cell
\pard\intbl 2,125 \cell
\pard\intbl 2% \cell
\pard\intbl 345 \cell
\pard\intbl 25% \cell
\pard\intbl 1,230 \cell
\pard\intbl 18% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Tamiflu \cell
\pard\intbl 3,200 \cell
\pard\intbl 435% \cell
\pard\intbl 906 \cell
\pard\intbl 110% \cell
\pard\intbl 784 \cell
\pard\intbl 5080% \cell
\pard\intbl 884 \cell
\pard\intbl 808% \cell
\pard\intbl 626 \cell
\pard\intbl 829% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Pegasys \cell
\pard\intbl 1,655 \cell
\pard\intbl 5% \cell
\pard\intbl 404 \cell
\pard\intbl 2% \cell
\pard\intbl 398 \cell
\pard\intbl -2% \cell
\pard\intbl 129 \cell
\pard\intbl 14% \cell
\pard\intbl 724 \cell
\pard\intbl 8% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl CellCept \cell
\pard\intbl 1,576 \cell
\pard\intbl -22% \cell
\pard\intbl 549 \cell
\pard\intbl -47% \cell
\pard\intbl 494 \cell
\pard\intbl 1% \cell
\pard\intbl 51 \cell
\pard\intbl 12% \cell
\pard\intbl 482 \cell
\pard\intbl 0% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl NeoRecormon/ Epogin \cell
\pard\intbl 1,560 \cell
\pard\intbl -11% \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl 679 \cell
\pard\intbl -19% \cell
\pard\intbl 515 \cell
\pard\intbl -1% \cell
\pard\intbl 366 \cell
\pard\intbl -5% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Tarceva \cell
\pard\intbl 1,304 \cell
\pard\intbl 10% \cell
\pard\intbl 521 \cell
\pard\intbl 5% \cell
\pard\intbl 475 \cell
\pard\intbl 11% \cell
\pard\intbl 67 \cell
\pard\intbl 28% \cell
\pard\intbl 241 \cell
\pard\intbl 18% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Xeloda \cell
\pard\intbl 1,260 \cell
\pard\intbl 7% \cell
\pard\intbl 473 \cell
\pard\intbl 10% \cell
\pard\intbl 311 \cell
\pard\intbl -3% \cell
\pard\intbl 77 \cell
\pard\intbl 40% \cell
\pard\intbl 399 \cell
\pard\intbl 9% \cell
\row
\trowd\trgaph100\cellx872\cellx1744\cellx2616\cellx3488\cellx4360\cellx5232\cellx6104\cellx6976\cellx7848\cellx8720\cellx9592
\pard\intbl Lucentis \cell
\pard\intbl 1,198 \cell
\pard\intbl 24% \cell
\pard\intbl 1,198 \cell
\pard\intbl 24% \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl - \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales of {\b Avastin } (bevacizumab), for advanced colorectal, breast, lung and kidney cancer, and for relapsed glioblastoma (a type of brain tumour), rose 21% to 6.2 billion Swiss francs. Solid double-digit growth was re-corded in all regions, driven primarily by continued uptake in colorectal, breast and lung cancer. Uptake in Japan, where Avastin is currently marketed for advanced colorectal cancer, remains particularly strong and is expected to be enhanced by the product\u8217?s recent approval for advanced non-small cell lung cancer. Sales growth in the United States is being driven mainly by use in advanced breast cancer and the new indications glioblastoma and kidney cancer, while high penetration rates were maintained in established indications such as lung and colorectal cancer. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Overall sales (oncology and rheumatoid arthritis) of {\b MabThera/Rituxan}  (rituximab), for non-Hodgkin\u8217?s lymphoma (NHL), chronic lymphocytic leukemia (CLL) and rheumatoid arthritis (RA), rose 6% to 6.1 billion Swiss francs. Sustained growth in the oncology segment was driven by uptake in CLL following approval in the EU for first-line treatment and in the relapsed/refractory disease setting in the first and third quarters, respectively. Lower sales growth in the US reflects the high levels of adoption of Rituxan in its cancer indications. Sales in the RA segment were an estimated 900 million Swiss francs, or 15% of the product\u8217?s total sales. Growth in this segment is being driven by increasing and earlier use of MabThera/Rituxan in patients with an inadequate response to one or more tumour necrosis factor (TNF) inhibitors. MabThera is well established as the medicine of choice following inadequate response to TNF inhibitor treatment and is currently the market leader in that segment in the EU. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales of {\b Herceptin } (trastuzumab), for HER2-positive breast cancer, increased 8% to 5.3 billion Swiss francs. Solid growth throughout the year was driven by continuing uptake for early breast cancer, especially in Japan and a number of emerging markets, as well as increasing market penetration in Eastern Europe. Moderate sales growth in the US and Western Europe reflects the high market penetration achieved in both early and advanced breast cancer in these regions.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales of {\b Tarceva } (erlotinib), for advanced lung and pancreatic cancer, increased 10% to 1.3 billion Swiss francs. Demand is being driven by increased use of the medicine in second-line non-small cell lung cancer (NSCLC) outside the US and in metastatic pancreatic cancer. The main sales contributions came from Western Europe and the United States. The more modest growth in US sales reflects stable penetration in NSCLC and pancreatic cancer, the competitive environment and reserve adjustments taken during the year, primarily for government programmes involving discounts. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales of {\b Xeloda } (capecitabine), for colorectal, stomach and breast cancer, increased 7% to 1.3 billion francs, driven primarily by strong gains in the United States, Japan and China. Growth is being driven by use in metastatic breast cancer, adjuvant colon cancer and metastatic colorectal cancer. In China the majority of growth is coming from use in patients with advanced stomach cancer, while in Japan Chugai recorded significant additional growth in the fourth quarter following approval of an expanded metastatic colorectal cancer indication. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Global sales of the anti-influenza medicine {\b Tamiflu } (oseltamivir) amounted to 3.2 billion Swiss francs in 2009, an increase of 435%, or 2.6 billion francs, compared with 2008. This very high growth was driven by unprecedented demand from governments and in the retail pharmacy sector following the pandemic A (H1N1) 2009 influenza virus (\u8216?swine flu\u8217?) outbreak, which began in April and spread rapidly worldwide. Sales for pandemic stockpiling amounted to 1.9 billion francs for the full-year. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Roche is working with national health authorities to expand approval for pandemic use of Tamiflu to include children less than one year of age, as well as pregnant and lactating women, and to gain regulatory approval for alternative methods of administering the medicine to infants and young children. The company also continues to cooperate closely with the World Health Organization and governments worldwide to support pandemic preparedness and supply Tamiflu to all patients in need. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales of {\b Pegasys } (peginterferon alfa-2a), for hepatitis B and C, totalled 1.7 billion Swiss francs in 2009, an increase of 5% over the previous year, driven by market-share gains in major markets. Growth is being helped by new study data demonstrating the superiority of Pegasys over other treatment options, increased use in the treatment of hepatitis B, and increasing rates of hepatitis diagnosis and treatment in emerging markets. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 US sales of {\b Lucentis } (ranibizumab), for wet age-related macular degeneration (AMD, the most common form of age-related blindness) rose 24% to 1.2 billion Swiss francs. Strong double-digit growth throughout 2009 was driven primarily by an increase in the number of injections administered to patients in the first and second year of treatment, growth in the number of patients treated for wet AMD and easier reimbursement. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 In a highly competitive, price-sensitive market, sales of the renal anemia medication {\b Mircera } (methoxy polyethylene glycol-epoetin beta), which is now available in over 80 markets worldwide, showed consistent growth throughout 2009, rising 252% to 179 million Swiss francs. Sales are being driven primarily by the success of the product in the predialysis segment. Combined sales of the Group\u8217?s established anemia medicines, Roche\u8217?s {\b NeoRecormon } and Chugai\u8217?s {\b Epogin } (epoetin beta), declined 11% to 1.6 billion Swiss francs. Outside Japan the combined market share of Roche\u8217?s anemia franchise (Mircera and NeoRecormon) continues to increase despite competition from new market entrants. The decline in NeoRecormon sales of 14% was due mainly to increased price pressure as new biosimilars enter the market. In contrast, the slight decline of Epogin in Japan (\u8211?1%) reflects stabilisation of the product\u8217?s market share in the dialysis segment and continued expansion in the predialysis setting. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Following EU marketing approval in January 2009, by year-end the novel rheumatoid arthritis (RA) medicine {\b RoActemra } (tocilizumab, known as Actemra outside Europe) had been launched in ten EU countries, including Germany, France, Spain and the United Kingdom. Sales uptake in the initial European launch markets has been strong. Following launches in additional markets, including Switzerland, India and Brazil, Actemra/RoActemra is now available in over 25 countries worldwide. The response from physicians is very encouraging. Global sales rose 289% to 146 million Swiss francs in 2009. In Japan, where Actemra was approved for RA in adults and for related pediatric indications in April 2008, adoption and market penetration are progressing well, with doctors already using the medicine as a first-line biologic treatment in many patients. Sales in Japan amounted to 98 million francs, an increase of 146%. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales of {\b CellCept } (mycophenolate mofetil), for the prevention of solid organ transplant rejection, decreased 22% compared with 2008 to 1.6 billion Swiss francs. Sales in the US, the product\u8217?s largest market, declined sharply from May onwards following expiry of the US patent. The continuing erosion of US sales through generic competition is being offset to some extent by solid growth elsewhere, especially in Latin America and Japan.\par}
{\pard\f0\sl360\fs22\b Development highlights \u8212? key marketed products\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 In 2009, the Pharmaceuticals Division filed 23 major new marketing applications and gained 13 major regulatory approvals. Positive results from 16 major phase III clinical trials investigating additional indications for existing key products or with new products such as taspoglutide and ocrelizumab were also reported. The following summaries present approvals, filings and major clinical trial results for key marketed products, by indication.\par}
{\pard
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Product \cell
\pard\intbl Active substance \cell
\pard\intbl Indication and/or dosage form \cell
\pard\intbl Country \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Avastin}  \cell
\pard\intbl bevacizumab \cell
\pard\intbl relapsed glioblastoma multiforme \cell
\pard\intbl Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl first-line metastatic breast cancer, combination with standard chemotherapy \cell
\pard\intbl EU, USA, Japan, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b ED-71}  \cell
\pard\intbl Eldecalcitol \cell
\pard\intbl osteoporosis \cell
\pard\intbl Japan \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Epogin}  \cell
\pard\intbl Epotein beta \cell
\pard\intbl chemotherapy-induced anemia \cell
\pard\intbl Japan \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Herceptin}  \cell
\pard\intbl trastuzumab \cell
\pard\intbl advanced HER2-positive gastric cancer \cell
\pard\intbl EU, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Lucentis}  \cell
\pard\intbl ranibizumab \cell
\pard\intbl macular edema following retinal vein occlusion \cell
\pard\intbl USA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b MabThera/Rituxan}  \cell
\pard\intbl rituximab \cell
\pard\intbl rheumatoid arthritis \u8212? patients with an inadequate response to a disease modifying anti-rheumatic drug; prevention of joint damage \cell
\pard\intbl EU, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl first-line chronic lymphocytic leukemia \cell
\pard\intbl USA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl relapsed or refractory chronic lymphocytic leukemia \cell
\pard\intbl EU, USA, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b RG744 (Mircera)}  \cell
\pard\intbl Methoxy-Polyethylen-glycol-Epotein beta \cell
\pard\intbl Renal anemia \cell
\pard\intbl Japan \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Tarceva}  \cell
\pard\intbl erlotinib \cell
\pard\intbl non small cell lung cancer, first line maintenance after chemotherapy  \cell
\pard\intbl EU, USA,, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl Advanced pancreatic cancer \cell
\pard\intbl Japan \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Xeloda}  \cell
\pard\intbl capecitabine \cell
\pard\intbl adjuvant colon cancer, combination with oxaliplatin  \cell
\pard\intbl EU, Switzerland \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 1 updated to 8 January 2010\par}
{\pard
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Product \cell
\pard\intbl Active substance \cell
\pard\intbl Indication and/or dosage form \cell
\pard\intbl Country \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Avastin}  \cell
\pard\intbl bevacizumab \cell
\pard\intbl relapsed glioblastoma multiforme \cell
\pard\intbl USA{\super 2} , Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl metastatic breast cancer; combination with docetaxel \cell
\pard\intbl EU, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl first-line metastatic renal cell carcinoma, combination with interferon alfa-2a \cell
\pard\intbl USA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl unresectable advanced or recurrent non-squamous non-small cell lung cancer \cell
\pard\intbl Japan  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b MabThera/Rituxan}  \cell
\pard\intbl rituximab \cell
\pard\intbl relapsed or refractory chronic lymphocytic leukemia \cell
\pard\intbl EU, Switzerland \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl first-line chronic lymphocytic leukemia \cell
\pard\intbl EU \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl rheumatoid arthritis, guidance on retreatment in patients with an inadequate response to anti-TNF therapy \cell
\pard\intbl USA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Actemra/RoActemra}  \cell
\pard\intbl tocilizumab \cell
\pard\intbl rheumatoid arthritis signs and symptoms \cell
\pard\intbl EU, USA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Xeloda}  \cell
\pard\intbl capecitabine \cell
\pard\intbl Advanced or refractory colorectal cancer, combination with oxaliplatin, with or without Avastin, \cell
\pard\intbl Japan \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 1 updated to 8 January 2010\line 2 Accelerated approval (FDA)\par}
{\pard
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Disease area  \cell
\pard\intbl Product \cell
\pard\intbl Indication \cell
\pard\intbl Study \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Oncology}  \cell
\pard\intbl MabThera/Rituxan \cell
\pard\intbl indolent non-Hodgkin\u8217?s lymphoma, first- line maintenance \cell
\pard\intbl PRIMA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Avastin \cell
\pard\intbl second-line metastatic breast cancer \cell
\pard\intbl RIBBON-2 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Xeloda \cell
\pard\intbl adjuvant treatment of colon cancer \cell
\pard\intbl NO16968 (XELOXA) \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Herceptin \cell
\pard\intbl HER2-positive stomach cancer \cell
\pard\intbl ToGA \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Tarceva  \cell
\pard\intbl non-small cell lung cancer (NSCLC), first-line maintenance treatment (overall survival data) \cell
\pard\intbl SATURN \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Tarceva + Avastin \cell
\pard\intbl NSCLC, first-line maintenance treatment \cell
\pard\intbl ATLAS \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Inflammation}  \cell
\pard\intbl Actemra \cell
\pard\intbl rheumatoid arthritis (RA), progression of joint damage \cell
\pard\intbl LITHE 2 -year-data \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Actemra \cell
\pard\intbl juvenile idiopathic arthritis, systemic onset \cell
\pard\intbl TENDER \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl ocrelizumab \cell
\pard\intbl RA, patients with inadequate response to previous treatment with MTX \cell
\pard\intbl STAGE \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Ophthalmology}  \cell
\pard\intbl Lucentis \cell
\pard\intbl macular edema following central retinal vein occlusion \cell
\pard\intbl CRUISE \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl Lucentis \cell
\pard\intbl Macular edema following branch retinal vein occlusion \cell
\pard\intbl BRAVO \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Metabolism}  \cell
\pard\intbl taspoglutide \cell
\pard\intbl type 2 diabetes \cell
\pard\intbl T-emerge 1, 2, 4, 5, 7 \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 \par}
{\pard\f0\sl360\fs22\b Research and development\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Over the next few years the division aims to expand its product portfolio with a new generation of medicines for patients suffering from cancer, metabolic and autoimmune diseases, viral infections and disorders of the central nervous system (CNS). Late-stage development of promising anticancer compounds such as pertuzumab and T\u8211?DM1 (HER2-positive breast cancer), RG7204 (malignant melanoma) and RG7159 (leukemia, lymphoma) is on track. In addition, two novel compounds in the metabolic and CNS portfolios - aleglitazar (cardiovascular disease in high-risk type 2 diabetes patients) and RG1678 (negative symptoms of schizophrenia) - are about to start phase III development. At the same time, we are also exploring new indications and formulations for existing products, including formulations of Herceptin and other biologic medicines that can be administered by more convenient subcutaneous injection instead of intravenous infusion.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 At the beginning of 2010 the division\u8217?s R&D pipeline included 111 projects in clinical development (phase I to III). Of these, 59 involved new molecular entities (NMEs) and 52 involved additional indications. Ten NMEs are in or about to enter late-stage development. 30 projects investigating additional indication for existing products are in Phase III. \par}
{\pard
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Compound \cell
\pard\intbl Lead indication \cell
\pard\intbl Status \cell
\pard\intbl Market potential \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b ocrelizumab}  \cell
\pard\intbl rheumatoid arthritis \cell
\pard\intbl first phase III study (STAGE) met primary endpoint in Q4 2009 \u8211? results from additional studies expected in 2010 \cell
\pard\intbl best in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b trastuzumab\u8211?DM1}  \cell
\pard\intbl HER2-positive metastatic breast cancer \cell
\pard\intbl phase III started Q1 2009 (2nd-line treatment) \cell
\pard\intbl first in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b pertuzumab}  \cell
\pard\intbl HER2-positive metastatic breast cancer \cell
\pard\intbl phase III started in 2008 \cell
\pard\intbl first in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b RG7159 (GA101)}  \cell
\pard\intbl non-Hodgkin\u8217?s lymphoma and chronic lymphocytic leukemia \cell
\pard\intbl phase III started Q4 2009 (chronic lymphocytic leukemia) \cell
\pard\intbl best in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b RG7204 (PLX4032)}  \cell
\pard\intbl malignant melanoma \cell
\pard\intbl registration studies started in 2009, January 2010  \cell
\pard\intbl first in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b RG3616 (hedgehog pathway inhibitor)}  \cell
\pard\intbl advanced basal cell carcinoma \cell
\pard\intbl pivotal phase II started Q1 2009 \cell
\pard\intbl first in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b RG1678 (GlyT-1 inhibitor)}  \cell
\pard\intbl negative symptoms of schizophrenia \cell
\pard\intbl positive phase II results in Q4 2009, phase III planned to start in 2010  \cell
\pard\intbl first in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b aleglitazar}  \cell
\pard\intbl cardiovascular high risk in type 2 diabetes \cell
\pard\intbl phase III planned to start in Q1 2010 \cell
\pard\intbl first in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b taspoglutide}  \cell
\pard\intbl type 2 diabetes \cell
\pard\intbl first positive phase III results (T-emerge) in Q4 2009, additional results expected in 2010 \cell
\pard\intbl best in class \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b dalcetrapib}  \cell
\pard\intbl dyslipidemia, cardiovascular high risk \cell
\pard\intbl phase III enrolment ongoing \cell
\pard\intbl first in class \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 {\b Division Diagnostics} \par}
{\pard
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl  \cell
\pard\intbl In millions of CHF \cell
\pard\intbl % change in CHF \cell
\pard\intbl % change in local currencies \cell
\pard\intbl % of sales \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Sales \cell
\pard\intbl 10,055 \cell
\pard\intbl 4 \cell
\pard\intbl 9 \cell
\pard\intbl 100 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? Professional Diagnostics  \cell
\pard\intbl 4,553 \cell
\pard\intbl 4 \cell
\pard\intbl 9 \cell
\pard\intbl 45 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? Diabetes Care  \cell
\pard\intbl 2,969 \cell
\pard\intbl 0 \cell
\pard\intbl 6 \cell
\pard\intbl 29 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? Molecular Diagnostics \cell
\pard\intbl 1,183 \cell
\pard\intbl 2 \cell
\pard\intbl 5 \cell
\pard\intbl 12 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl \u8211? Applied Science \cell
\pard\intbl 870 \cell
\pard\intbl 12 \cell
\pard\intbl 15 \cell
\pard\intbl 9 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl - Tissue Diagnostics \cell
\pard\intbl 480 \cell
\pard\intbl 28 \cell
\pard\intbl 29 \cell
\pard\intbl 5 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Operating profit  \cell
\pard\intbl 1,198 \cell
\pard\intbl 1 \cell
\pard\intbl 12 \cell
\pard\intbl 11.9 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Operating free cash flow \cell
\pard\intbl 1,152 \cell
\pard\intbl 92 \cell
\pard\intbl 102 \cell
\pard\intbl 11.5 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Research and development \cell
\pard\intbl 978 \cell
\pard\intbl 4 \cell
\pard\intbl 5 \cell
\pard\intbl 9.7 \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 In 2009, the Diagnostics Division recorded sales of 10.1 billion Swiss francs, an increase of 9% in local currencies (4% in Swiss francs and in US dollars) over 2008. This was more than twice the estimated growth rate of the in vitro diagnostics market (3\u8211?4%).\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 All five divisional business areas contributed to sales growth, led by Professional Diagnostics and Diabetes Care. Immunoassays and single-strip blood glucose monitoring systems remained these businesses\u8217? primary growth drivers. Molecular Diagnostics\u8217? core blood screening and virology segments delivered a solid single-digit rise in overall sales. In the Applied Science unit, strong demand for the MagNA Pure and LightCycler product lines fuelled further above-market growth. The Tissue Diagnostics business, acquired in 2008, continued to grow well ahead of the market, driven mainly by its advanced tissue staining portfolio. Instrument placements were again up significantly for the division as a whole and were a major growth driver.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Geographically, the EMEA{\super 1}  and Asia\u8211?Pacific regions contributed most to growth, with all five business areas recording solid sales gains in these markets. Tissue Diagnostics remained the primary growth driver in North America. In Japan, Professional Diagnostics and Applied Science grew moderately and Tissue Diagnostics achieved high double-digit growth, but divisional sales there were flat overall, largely due to reduced government IVD reimbursement and lower research funding.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Sales in the E7{\super 2}  \u160?markets grew 24% and accounted for over 10% of total divisional sales revenues. Increased investment in these markets and strong demand for immunoassays and other leading-edge Roche products contributed to this strong, above-market growth.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The first two modules of the cobas 8000 analyser series for high-throughput laboratories were launched on schedule in the EU and other markets in the second half of the year. Roche expects this major addition to its cobas family of modular Serum Work Area systems to enhance its competitiveness significantly in both clinical chemistry and immunoassays. Altogether, the division launched over 20 major products in 2009.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The Diagnostic Division\u8217?s operating profit rose 12% in local currencies (1% in Swiss francs) to 1,198 million Swiss francs, and the operating margin at constant exchange rates advanced 0.4 percentage points. These increases largely reflect sales growth, tight cost management and the significant one-time expenses recorded in 2008, including those relating to the Ventana acquisition. In Swiss francs, the margin decreased by 0.4 percentage points, to 11.9%, due to a particularly unfavourable combination of exchange rate movements.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 1) EMEA = Europe, Middle East and Africa.\line 2) E7= Brazil, Russia, India, China, South Korea, Mexico and Turkey\par}
{\pard\f0\sl360\fs22\b About Roche\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world\u8217?s largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche\u8217?s personalised healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2009, Roche had over 80\u8217?000 employees worldwide and invested almost 10 billion Swiss francs in R&D. The Group posted sales of 49.1 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. For more information: www.roche.com.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs18 All trademarks used or mentioned in this release are protected by law.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs18 Disclaimer: Cautionary statement regarding forward-looking statements\line This document contains certain forward-looking statements. These forward-looking statements may be identified by words such as \u8216?believes\u8217?, \u8216?expects\u8217?, \u8216?anticipates\u8217?, \u8216?projects\u8217?, \u8216?intends\u8217?, \u8216?should\u8217?, \u8216?seeks\u8217?, \u8216?estimates\u8217?, \u8216?future\u8217? or similar expressions or by discussion of, among other things, strategy, goals, plans or intentions. Various factors may cause actual results to differ materially in the future from those reflected in forward-looking statements contained in this document, among others: (1) pricing and product initiatives of competitors; (2) legislative and regulatory developments and economic conditions; (3) delay or inability in obtaining regulatory approvals or bringing products to market; (4) fluctuations in currency exchange rates and general financial market conditions; (5) uncertainties in the discovery, development or marketing of new products or new uses of existing products, including without limitation negative results of clinical trials or research projects, unexpected side-effects of pipeline or marketed products; (6) increased government pricing pressures; (7) interruptions in production; (8) loss of or inability to obtain adequate protection for intellectual property rights; (9) litigation; (10) loss of key executives or other employees; and (11) adverse publicity and news coverage. The statement regarding earnings per share growth is not a profit forecast and should not be interpreted to mean that Roche\u8217?s earnings or earnings per share for any current or future period will necessarily match or exceed the historical published earnings or earnings per share of Roche.\par}
{\pard
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl in millions of CHF \cell
\pard\intbl Pharma \cell
\pard\intbl Diagnostics \cell
\pard\intbl Corporate \cell
\pard\intbl Group \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl {\b Sales}  \cell
\pard\intbl 38,996 \cell
\pard\intbl 10,055 \cell
\pard\intbl - \cell
\pard\intbl 49,051 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Royalties and other operating income \cell
\pard\intbl 1,948 \cell
\pard\intbl 152 \cell
\pard\intbl - \cell
\pard\intbl 2,100 \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Cost of sales \cell
\pard\intbl (9,535) \cell
\pard\intbl (5,080) \cell
\pard\intbl - \cell
\pard\intbl (14,615) \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Marketing and distribution \cell
\pard\intbl (6,964) \cell
\pard\intbl (2,511) \cell
\pard\intbl - \cell
\pard\intbl (9,475) \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Research and development{\super  }  \cell
\pard\intbl (8,896) \cell
\pard\intbl (978) \cell
\pard\intbl - \cell
\pard\intbl (9,874) \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl General and administration \cell
\pard\intbl (1,395) \cell
\pard\intbl (440) \cell
\pard\intbl (340) \cell
\pard\intbl (2,175) \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl {\b Operating profit before exceptional items }  \cell
\pard\intbl {\b 14,154}  \cell
\pard\intbl {\b 1,198}  \cell
\pard\intbl {\b (340)}  \cell
\pard\intbl {\b 15,012}  \cell
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\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Major legal cases  \cell
\pard\intbl (320) \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl (320) \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Changes in Group organisation  \cell
\pard\intbl (2,415) \cell
\pard\intbl - \cell
\pard\intbl - \cell
\pard\intbl (2,415) \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl {\b Operating profit }  \cell
\pard\intbl {\b 11,419}  \cell
\pard\intbl {\b 1,198}  \cell
\pard\intbl {\b (340)}  \cell
\pard\intbl {\b 12,277}  \cell
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\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
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\pard\intbl Associates  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Financial income  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 792}  \cell
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\pard\intbl Financing costs  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b (2,460)}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Exceptional financing costs \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b (377)}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl {\b Profit before taxes}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 10,232}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Income taxes  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b (2,870)}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Income taxes on exceptional items  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 1,148}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl {\b Net income}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 8,510}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Attributable to  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl - Roche shareholders \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 7,784}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl - Non-controlling interests \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 726}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl {\b Earnings per share and non-voting equity security }  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Basic (CHF) \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 9.07}  \cell
\row
\trowd\trgaph100\cellx1920\cellx3840\cellx5760\cellx7680\cellx9600
\pard\intbl Diluted (CHF) \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl {\b 9.02}  \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 \par}
{\pard
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl in millions of CHF \cell
\pard\intbl 31 December 2009 \cell
\pard\intbl 31 December 2008 \cell
\pard\intbl 31 December 2007 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Non-current assets}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Property, plant and equipment  \cell
\pard\intbl 17,697 \cell
\pard\intbl 18,190 \cell
\pard\intbl 17,832 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Goodwill  \cell
\pard\intbl 8,261 \cell
\pard\intbl 8,353 \cell
\pard\intbl 6,835 \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Intangible assets  \cell
\pard\intbl 6,005 \cell
\pard\intbl 7,121 \cell
\pard\intbl 6,346 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Associates  \cell
\pard\intbl 16 \cell
\pard\intbl 9 \cell
\pard\intbl 9 \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Financial long-term assets  \cell
\pard\intbl 481 \cell
\pard\intbl 940 \cell
\pard\intbl 1,333 \cell
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\pard\intbl Other long-term assets  \cell
\pard\intbl 452 \cell
\pard\intbl 451 \cell
\pard\intbl 527 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Deferred income tax assets  \cell
\pard\intbl 2,573 \cell
\pard\intbl 1,829 \cell
\pard\intbl 1,317 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Post-employment benefit assets  \cell
\pard\intbl 601 \cell
\pard\intbl 592 \cell
\pard\intbl 1,332 \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total non-current assets}  \cell
\pard\intbl {\b 36,086}  \cell
\pard\intbl {\b 37,485}  \cell
\pard\intbl {\b 35,531}  \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Current assets}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Inventories  \cell
\pard\intbl 5,648 \cell
\pard\intbl 5,830 \cell
\pard\intbl 6,113 \cell
\row
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\pard\intbl Accounts receivable  \cell
\pard\intbl 10,461 \cell
\pard\intbl 9,755 \cell
\pard\intbl 9,804 \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Current income tax assets  \cell
\pard\intbl 244 \cell
\pard\intbl 268 \cell
\pard\intbl 263 \cell
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\pard\intbl 3,577 \cell
\pard\intbl 1,980 \cell
\pard\intbl 2,452 \cell
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\pard\intbl Marketable securities  \cell
\pard\intbl 16,107 \cell
\pard\intbl 15,856 \cell
\pard\intbl 20,447 \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Cash and cash equivalents  \cell
\pard\intbl 2,442 \cell
\pard\intbl 4,915 \cell
\pard\intbl 3,755 \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total current assets}  \cell
\pard\intbl {\b 38,479}  \cell
\pard\intbl {\b 38,604}  \cell
\pard\intbl {\b 42,834}  \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total assets}  \cell
\pard\intbl {\b 74,565}  \cell
\pard\intbl {\b 76,089}  \cell
\pard\intbl {\b 78,365}  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Non-current liabilities}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Long-term debt  \cell
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\pard\intbl (2,972) \cell
\pard\intbl (3,834) \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Deferred income tax liabilities  \cell
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\pard\intbl (1,409) \cell
\pard\intbl (1,527) \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Post-employment benefit liabilities  \cell
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\pard\intbl (4,669) \cell
\pard\intbl (3,696) \cell
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\pard\intbl Provisions  \cell
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\pard\intbl (654) \cell
\pard\intbl (688) \cell
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\pard\intbl Other non-current liabilities  \cell
\pard\intbl (416) \cell
\pard\intbl (459) \cell
\pard\intbl (723) \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total non-current liabilities}  \cell
\pard\intbl {\b (43,084)}  \cell
\pard\intbl {\b (10,163)}  \cell
\pard\intbl {\b (10,468)}  \cell
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\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
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\pard\intbl {\b Current liabilities}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Short-term debt  \cell
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\pard\intbl (1,117) \cell
\pard\intbl (3,032) \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Current income tax liabilities  \cell
\pard\intbl (2,478) \cell
\pard\intbl (2,193) \cell
\pard\intbl (2,215) \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Provisions  \cell
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\pard\intbl (804) \cell
\pard\intbl (1,517) \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Accounts payable  \cell
\pard\intbl (2,300) \cell
\pard\intbl (2,017) \cell
\pard\intbl (1,861) \cell
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\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Accrued and other current liabilities  \cell
\pard\intbl (9,398) \cell
\pard\intbl (5,973) \cell
\pard\intbl (5,829) \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total current liabilities}  \cell
\pard\intbl {\b (22,067)}  \cell
\pard\intbl {\b (12,104)}  \cell
\pard\intbl {\b (14,454)}  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total liabilities}  \cell
\pard\intbl {\b (65,151)}  \cell
\pard\intbl {\b (22,267)}  \cell
\pard\intbl {\b (24,922)}  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total net assets}  \cell
\pard\intbl {\b 9,414}  \cell
\pard\intbl {\b 53,822}  \cell
\pard\intbl {\b 53,443}  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Equity}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Capital and reserves attributable to Roche shareholders  \cell
\pard\intbl 7,366 \cell
\pard\intbl 44,479 \cell
\pard\intbl 45,483 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl Equity attributable to non-controlling interests  \cell
\pard\intbl 2,048 \cell
\pard\intbl 9,343 \cell
\pard\intbl 7,960 \cell
\row
\trowd\trgaph100\cellx2400\cellx4800\cellx7200\cellx9600
\pard\intbl {\b Total equity}  \cell
\pard\intbl {\b 9,414}  \cell
\pard\intbl {\b 53,822}  \cell
\pard\intbl {\b 53,443}  \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 \par}
{\pard
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl in millions of CHF \cell
\pard\intbl 2009 \cell
\pard\intbl 2008 \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Cash flows from operating activities}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Cash generated from operations \cell
\pard\intbl {\b 19,304}  \cell
\pard\intbl {\b 17,626}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl (Increase) decrease in working capital \cell
\pard\intbl {\b 349}  \cell
\pard\intbl {\b (524)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Payments made for defined benefit post-employment plans  \cell
\pard\intbl {\b (467)}  \cell
\pard\intbl {\b (353)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Utilisation of provisions  \cell
\pard\intbl {\b (709)}  \cell
\pard\intbl {\b (1,061)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Other operating cash flows \cell
\pard\intbl {\b 167}  \cell
\pard\intbl {\b 3}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Cash flows from operating activities, before income taxes paid}  \cell
\pard\intbl {\b 18,644}  \cell
\pard\intbl {\b 15,691}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Income taxes paid \cell
\pard\intbl {\b (1,767)}  \cell
\pard\intbl {\b (3,514)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Total cash flows from operating activities}  \cell
\pard\intbl {\b 16,877}  \cell
\pard\intbl {\b 12,177}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Cash flows from investing activities}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Purchase of property, plant and equipment \cell
\pard\intbl {\b (2,984)}  \cell
\pard\intbl {\b (3,139)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Purchase of intangible assets \cell
\pard\intbl {\b (235)}  \cell
\pard\intbl {\b (418)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Disposal of property, plant and equipment \cell
\pard\intbl {\b 113}  \cell
\pard\intbl {\b 69}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Disposal of intangible assets \cell
\pard\intbl {\b 3}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Disposal of products \cell
\pard\intbl {\b 169}  \cell
\pard\intbl {\b 472}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Business combinations  \cell
\pard\intbl {\b (98)}  \cell
\pard\intbl {\b (3,004)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Divestments of subsidiaries  \cell
\pard\intbl {\b 15}  \cell
\pard\intbl {\b 40}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Interest and dividends received  \cell
\pard\intbl {\b 306}  \cell
\pard\intbl {\b 611}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Sales of marketable securities \cell
\pard\intbl {\b 14,968}  \cell
\pard\intbl {\b 16,666}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Purchases of marketable securities \cell
\pard\intbl {\b (15,171)}  \cell
\pard\intbl {\b (12,758)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Other investing cash flows \cell
\pard\intbl {\b 5}  \cell
\pard\intbl {\b (261)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Total cash flows from investing activities}  \cell
\pard\intbl {\b (2,909)}  \cell
\pard\intbl {\b (1,722)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Cash flows from financing activities}  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Proceeds from issue of bonds and notes \cell
\pard\intbl {\b 48,197}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Redemption and repurchase of bonds and notes  \cell
\pard\intbl {\b (7,421)}  \cell
\pard\intbl {\b (2,188)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Increase (decrease) in commercial paper \cell
\pard\intbl {\b (261)}  \cell
\pard\intbl {\b (107)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Increase (decrease) in other debt \cell
\pard\intbl {\b (133)}  \cell
\pard\intbl {\b (317)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Hedging and collateral arrangements  \cell
\pard\intbl {\b 3,264}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Change in ownership interest in subsidiaries \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl - Genentech  \cell
\pard\intbl {\b (52,708)}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl - Chugai  \cell
\pard\intbl {\b -}  \cell
\pard\intbl {\b (934)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl - Ventana  \cell
\pard\intbl {\b -}  \cell
\pard\intbl {\b (1,285)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl - Memory  \cell
\pard\intbl {\b (6)}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Interest paid \cell
\pard\intbl {\b (748)}  \cell
\pard\intbl {\b (216)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Dividends paid \cell
\pard\intbl {\b (4,395)}  \cell
\pard\intbl {\b (4,051)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Genentech \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl - Genentech equity compensation plans  \cell
\pard\intbl {\b 108}  \cell
\pard\intbl {\b 735}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl - Genentech share repurchases  \cell
\pard\intbl {\b -}  \cell
\pard\intbl {\b (844)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Equity-settled equity compensation plans, net of transactions in own equity instruments  \cell
\pard\intbl {\b (651)}  \cell
\pard\intbl {\b (235)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Chugai share repurchases \cell
\pard\intbl {\b (14)}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Other financing cash flows \cell
\pard\intbl {\b -}  \cell
\pard\intbl {\b -}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Total cash flows from financing activities}  \cell
\pard\intbl {\b (14,768)}  \cell
\pard\intbl {\b (9,442)}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl  \cell
\pard\intbl  \cell
\pard\intbl  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Net effect of currency translation on cash and cash equivalents \cell
\pard\intbl {\b (1,673)}  \cell
\pard\intbl {\b 147}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Increase (decrease) in cash and cash equivalents}  \cell
\pard\intbl {\b (2,473)}  \cell
\pard\intbl {\b 1,160}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl Cash and cash equivalents at 1 January \cell
\pard\intbl {\b 4,915}  \cell
\pard\intbl {\b 3,755}  \cell
\row
\trowd\trgaph100\cellx3200\cellx6400\cellx9600
\pard\intbl {\b Cash and cash equivalents at 31 December }  \cell
\pard\intbl {\b 2,442}  \cell
\pard\intbl {\b 4,915}  \cell
\row
}
{\pard\f0\li0\ri0\sa360\sl360\fs22 \par}
{\pard\f0\sa120\sl360\fs30\i Additional information\par}
{\pard\f0\li440\ri0\sl360\fs22 - Annual Report 2009 ( http://www.roche.com/investors/annual_reports)\par}
{\pard\f0\li440\ri0\sl360\fs22 - Tables ( http://www.roche.com/mrar09ane.pdf)\par}
{\pard\f0\li440\ri0\sl360\fs22 - Presentations / media conference broadcast ( http://www.roche.com/media/events/bmk2010)\par}
{\pard\f0\li440\ri0\sl360\fs22 - Photographs of the media conference (http://download.roche.com/selection/20100203/)\par}
{\pard\f0\li440\ri0\sl360\fs22 - Roche Pharma pipeline ( http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline)\par}
{\pard\f0\li440\ri0\sl360\fs22 - Roche Diagnostics pipeline ( http://www.roche.com/research_and_development/pipeline/diagnostics_portfolio)\par}
{\pard\f0\li440\ri0\sl360\fs22 - Roche Finance Info System (http://rofis.roche.com/dynasight/rofis.html)\par}\line 

{\pard \par}
{\pard\sb180\f1\fs22 {\b F. Hoffmann-La Roche Ltd}\line 4070 Basel\line Switzerland \par}
{\pard\sb180\f1\fs22 Corporate Communications\line Roche Group Media Relations \par}
{\pard\sb180\f1\fs22 Tel. +41 61 688 88 88\line Fax +41 61 688 27 75\line www.roche.com \par}
}