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{\pard\sa900\fs50\f0\i Media Release\par}

{\pard\f0\li0\ri0\sa360\sl360\fs22 Basel/San Francisco, 13. September 2009\par}
{\pard\f0\sl360\fs22\b Two new studies report increased survival rates in Tamiflu-treated patients with avian flu (H5N1) and severe seasonal flu \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 53% of patients with H5N1 infection survived when treated with Tamiflu compared with 12% of untreated patients \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Rate of death was reduced by 37% in high-risk patients with severe seasonal flu compared with no treatment\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Tamiflu (oseltamivir) demonstrated significantly improved survival rates in patients with the highly pathogenic H5N1 influenza (avian flu) and severe cases of seasonal influenza, according to two new studies presented at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco {\super 1,2)} . \u160?\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 \u8220?In two different observational studies, the data continues to indicate that there is clinical benefit provided by Tamiflu, including improving survival in patients with H5N1 infection or seasonal influenza\u8221?, said Jean-Jacques Garaud, Global Head of Pharma Development at Roche. \u8220?Both studies reinforce the important role that Tamiflu can provide particularly among the most vulnerable patients and those infected with the most deadly strains\u8221?.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 This is the first multinational study to systematically assess human H5N1 infection. The study, which retrospectively examined outcomes in 215 patients from 10 countries, showed that the H5N1 virus had an extremely high mortality rate of 88%, with only 11 out of 89 untreated patients surviving. In contrast, 45 out of 85 (53%) patients who received at least one dose of Tamiflu survived. Furthermore, among the subset of patients who received Tamiflu within 2 days of symptom onset, an even higher percentage (71%; 5 out of 7 patients) survived. These data confirm the importance of prompt diagnosis and treatment with Tamiflu. The study also showed that there was some survival benefit even in patients that initiated treatment 6 to 8 days after symptom onset compared to untreated patients. This provides important evidence to support treatment even in those patients who present late with influenza symptoms.{\super 1} \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The research is based on a collaborative analysis conducted by the Avex Avian Influenza Expert Group, Outcomes Research, and the London School of Hygiene and Tropical Medicine. The study is supported by Roche.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 The H5N1 virus continues to spread throughout parts of Southeast Asia and Africa. Since 2003, the WHO has reported 438 human cases of H5N1, 262 of them fatal {\super 3} . \u160?Most recently, 2 new human cases were reported in Egypt on August 11, 2009. \par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 A second study conducted by the Chinese University of Hong Kong analysed 760 patients hospitalised with severe seasonal influenza during 2007-2008. Half of these patients received Tamiflu. The majority of these patients were older (mean age 70\u177?18 years) and 60% had underlying chronic illnesses. These data showed that the rate of death was reduced by 37% in patients treated with Tamiflu compared to patients who were not treated [3.8% treated vs. 6.0% untreated; adjusted Hazard Ratio 0.38(0.19,0.78)].{\super 2}  These data indicate that treatment with Tamiflu in high risk patients with severe influenza reduced mortality.\par}
{\pard\f0\sl360\fs22\b About Tamiflu\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Tamiflu, co-developed by Gilead Sciences Inc, is designed to be active against all clinically relevant influenza viruses and works by blocking the action of the neuraminidase enzyme on the surface of the virus. When neuraminidase is inhibited, the spread of the virus to other cells in the body is inhibited. Tamiflu is indicated for the treatment and prevention of uncomplicated influenza caused by type A and B viruses in patients one year and older.\par}
{\pard\f0\sl360\fs22\b About Roche\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world\u8217?s largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche\u8217?s personalised healthcare strategy aims to provide medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients.In 2008, Roche had over 80,000 employees worldwide and invested almost 9 billion Swiss francs in R&D.The Group posted sales of 45.6 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. For more information: www.roche.com.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs18 All trademarks used or mentioned in this release are protected by law.\par}
{\pard\f0\li0\ri0\sa360\sl360\fs18 Refereences\line 1) Toovey S. Avex Avian Influenza Expert Group. First results from an avian influenza case registry. Oral presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 2009. Abstract V-533, 9/13/2009\line 2) N Lee, et al. Outcomes of adults hospitalised with influenza 2007-2008. Poster presented at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 2009. Abstract V-1074k, 9/13/2009\line 3) Cumulative number of confirmed human cases of avian influenza A/(H5N1) Reported to WHO, 11 August 2009. http://www.who.int/csr/disease/avian_influenza/country/cases_table_2009_08_11/en/index.html (last accessed 03/09/2009) \par}
{\pard\f0\sa120\sl360\fs30\i Related Links\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Media Briefing: Update on influenza pandemic and Tamiflu ( http://www.roche.com/media/events/media-briefing-flu-2009)\par}

{\pard \par}
{\pard\sb180\f1\fs22 {\b F. Hoffmann-La Roche Ltd}\line 4070 Basel\line Switzerland \par}
{\pard\sb180\f1\fs22 Corporate Communications\line Roche Group Media Relations \par}
{\pard\sb180\f1\fs22 Tel. +41 61 688 88 88\line Fax +41 61 688 27 75\line www.roche.com \par}
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