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{\pard\sa900\fs50\f0\i Media Release\par}
{\pard\f0\li0\ri0\sa360\sl360\fs22 Basel, 24 August 2005\line \line {\b Roche 
donates 3 million treatments of antiviral Tamiflu to the WHO for use in an influenza pandemic} \line \line Roche 
announced today that it will donate 3 million treatments, or 30 million doses, of the antiviral Tamiflu 
(oseltamivir) to the World Health Organization (WHO). This "Rapid Response Stockpile" can 
be used by the WHO at the site of a new and potentially pandemic outbreak of human influenza, in order 
to reduce morbidity and mortality and to contain or delay the spread of this outbreak. Should such an 
outbreak occur, the WHO will work in partnership with the country concerned to co-ordinate the distribution 
of the antiviral and to promote the most effective use of the product.\line \line "We 
realize how important it is for governments to have stockpiles of Tamiflu in place when an influenza 
pandemic hits, as the production lead time is about 12 months. In order to increase the availability 
of the drug, we have taken steps to increase our manufacturing capacity, doubling manufacturing capacity 
both in 2004 and again in 2005, with further increase planned in 2006. In addition, manufacturing facilities 
producing Tamiflu have increased from one to three, with a fourth facility available later in 2005", 
commented William M. Burns, CEO Division Roche Pharma. \u8220?We believe that with these forward looking actions 
we are well placed in our collaboration with world governments on their plans to manage a potential 
health crisis\u8221?.\line \line "This donation is a critical early step designed 
to directly 
address an influenza pandemic at the place of origin, thereby potentially slowing the initial national 
and international spread of the virus. An influenza pandemic would be a serious threat to public health, 
and it is therefore critical that all countries take steps now to follow the WHO guidance and ensure 
that local pandemic plans are in place" commented. LEE Jong-wook, the Director-General of the World 
Health Organization. \line  
Roche and the WHO underscore that the "Rapid Response Stockpile"is not a replacement for national 
antiviral stockpiles which should be considered as one of a number 
of measures of national pandemic preparedness consistent with the national priorities of each country.\line \line Influenza 
pandemics occur approximately every 40 years, and experts caution that it is a case of when, not if, 
the next pandemic will strike. \line The H5N1 avian influenza strain originating in Asia is 
considered by experts to be the most likely source of the next pandemic. Tamiflu is designed to be active 
against all clinically relevant influenza viruses, including H5N1, and data suggest it could be effective 
against any mutating strain of the virus\u8211? the key to a pandemic. An orally administered treatment, Tamiflu 
is systemically active, and can protect against the virus at all sites in the body, whilst currently, 
other neuraminidase inhibitors can only provide protection from influenza within the lungs.\line \line Roche 
has been working with many governments over the last few months to discuss their needs for stockpiling 
of Tamiflu and has received and fulfilled orders from around 30 countries. The magnitude of these orders 
varies from country to country: for instance, France, Finland, Iceland, Ireland, Luxembourg, Netherlands, 
New Zealand, Norway, Switzerland, and the UK are stockpiling or intending to stockpile adequate Tamiflu 
supplies to cover 20-40% of their population.\line \line {\b About Tamiflu 
(oseltamivir)} \line Tamiflu 
is designed to be active against all clinically relevant influenza viruses. It works by blocking the 
action of the neuraminidase enzyme on the surface of the virus. When neuraminidase is inhibited, the 
virus is not able to spread to and infect other cells in the body.\line Tamiflu delivers:\par}{\pard\f0\li440\ri0\sl360\fs22 - 38 
percent reduction in the severity of symptoms\par}{\pard\f0\li440\ri0\sl360\fs22 - 67 percent reduction 
in secondary complications such as bronchitis, pneumonia and sinusitis in otherwise healthy individuals 
\par}{\pard\f0\li440\ri0\sl360\fs22 - 37 percent reduction in the duration of influenza illness\par}{\pard\f0\li440\ri0\sl360\fs22 - Tamiflu 
was shown to provide up to 89 percent overall protective efficacy against clinical influenza 
in adults and adolescents who had been in close contact with influenza-infected patients\par}\line {\pard\f0\li0\ri0\sa360\sl360\fs22 In 
children, Tamiflu delivers:\par}{\pard\f0\li440\ri0\sl360\fs22 - 36 percent reduction 
in the severity and duration of influenza symptoms\par}{\pard\f0\li440\ri0\sl360\fs22 - 44 percent reduced 
incidence of associated otitis media as compared to standard care\par}\line {\pard\f0\li0\ri0\sa360\sl360\fs22 {\b Avian 
Influenza and Pandemics} \line Most avian influenza viruses are not infectious to humans, 
but, 
should an avian and a human influenza virus co-infect a human or a pig, the virus strains can join, 
mutate and create a completely new virus, which may be transmissible from animals to humans, and from 
humans to humans. Such a strain would be entirely new in composition, so vaccines developed and administered 
to date to protect humans during seasonal epidemics, would be ineffective against this new strain, leaving 
the population vulnerable to infection. Experts believe the next influenza pandemic could result from 
such a mutation of virus strains.\line \line {\b World Health Organisation} \line The 
WHO has recommended as part of its Pandemic Preparedness Plan that countries establish stockpiles of 
antiviral treatments such as Tamiflu, which are effective against all strains of the influenza virus. 
The Pandemic Preparedness Plan, along with details of the 15 countries that have implemented national 
plans, can be viewed on the web (http://www.who.int/csr/resources/publications/influenza/WHO_CDS_CSR_GIP_2005_5/en/index.html).\line \line {\b About 
Roche} \line Headquartered in Basel, Switzerland, Roche is one of the world\u8217?s leading 
research-focused 
healthcare groups in the fields of pharmaceuticals and diagnostics. As a supplier of innovative products 
and services for the early detection, prevention, diagnosis and treatment of disease, the Group contributes 
on a broad range of fronts to improving people\u8217?s health and quality of life. Roche is a world leader 
in diagnostics, the leading supplier of medicines for cancer and transplantation and a market leader 
in virology. In 2004 sales by the Pharmaceuticals Division totalled 21.7 billion Swiss francs, while 
the Diagnostics Division posted sales of 7.8 billion Swiss francs. Roche employs roughly 65,000 people 
in 150 countries and has R&D agreements and strategic alliances with numerous partners, including 
majority ownership interests in Genentech and Chugai.\line \line {\pard\f0\li0\ri0\sa360\sl360\fs18 All 
trademarks 
used or mentioned in this release are legally protected.\par}\line \line \line {\b Additional 
information} \line - Roche Health Kiosk, Influenza (http://www.health-kiosk.ch/start_grip.htm)\line - 
About Tamiflu ( http://www.roche.com/med_mbtamiflu05e.pdf)\line - About influenza ( http://www.roche.com/med_mbinfluenza05e.pdf)\line - 
WHO: Global influenza programme (http://www.who.int/csr/disease/influenza/en/)\line - WHO: Avian 
flu (http://www.who.int/mediacentre/factsheets/avian_influenza/en/)\par}
{\pard \par}
{\pard\sb180\f1\fs22 {\b F. Hoffmann-La Roche Ltd}\line 4070 Basel\line Switzerland \par}
{\pard\sb180\f1\fs22 Corporate Communications\line Roche Group Media Relations \par}
{\pard\sb180\f1\fs22 Tel. +41 61 688 88 88\line Fax +41 61 688 27 75\line www.roche.com \par}
}