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Media Release

Basel, 10 May 2004

New 10 year agreement between Roche and Hitachi to become market leader in multibillion dollar immunochemistry sector
Continued unique partnership will strengthen position and build on growth

Roche Diagnostics and Hitachi High-Technologies Corporation, Tokyo, continue their plans to strengthen their position in the immunochemistry market. The new 10 year collaboration is a further significant step forward into the multibillion Dollar immunochemistry business based on laboratory automation solutions providing essential medical information to physicians.

This new agreement follows a very successful 25-years long partnership between the two companies in the area of automated analytical systems for clinical laboratories. This market, the biggest segment of the in-vitro-diagnostics market, is estimated to be worth 6.8 billion $US today. Under the terms of the new agreement, Roche Diagnostics and Hitachi High- Technologies will continue to jointly innovate and develop future laboratory automation solutions responding to the need to supply fast and reliable patient data.

“The new agreement marks another important milestone in our successful partnership and we have ensured the continuity of our collaboration for the next 10 years. We firmly believe that our renewed commitment will maximize our respective positions in the highly competitive In-Vitro Diagnostics market,” states Heino von Prondzynski, Head of Roche Diagnostics and a member of Roche’s Corporate Executive Committee. “We will continue to focus on innovations and new technology concepts to support healthcare professionals in their efforts to optimize care and help people in urgent need.”

“With this new contract Hitachi High- Technologies and Roche Diagnostics will continue to enhance the value of the clinical laboratory in the health care delivery process. We are excited about the opportunities which lie ahead of us” says Dr. Katsuji Yamashita, Senior Vice President , Executive Officer and General Manager of Life Science Business Group of Hitachi High-Technologies.

About Immunochemistry
Valued at 6.8 billion $US today, immunochemistry is the biggest part of the in-vitro diagnostics market. In the first three months this year Roche Diagnostics has recorded a significant double digit growth of 24% (27% in CHF) in this market. Immunochemistry assays are based on an “antigen-antibody” reaction. The presence of specific antigens and / or antibodies in the body can be a very clear indication of specific diseases or functional disorders, for example Elecsys proBNP for heart insufficiency. Like a specific key which fits with the respective lock there is a high specificity of the anti-body and anti-gen reaction thus allowing the use of these molecules as indicators for diseases or disorders. Roche’s Elecsys system is based on electrochemiluminescence (ECL) technology and has become a cornerstone in the central laboratory.

About Hitachi High-Technologies
Headquartered in Tokyo, Japan, Hitachi High-Technologies Corporation is a global trading company. Hitachi High-Technologies is engaged in developmental and marketing activities in a broad range of fields that include semiconductor manufacturing, scientific equipment, testing and evaluation equipment, information systems, semiconductors, and leading-edge materials. Hitachi High-Technologies has earned a reputation as a “high-tech integrator”.

About Roche
Headquartered in Basel, Switzerland, Roche is one of the world’s leading innovation-driven healthcare groups. Its core businesses are pharmaceuticals and diagnostics. Roche is number one in the global diagnostics market, the leading supplier of pharmaceuticals for cancer and a leader in virology and transplantation. As a supplier of products and services for the prevention, diagnosis and treatment of disease, the Group contributes on a broad range of fronts to improving people’s health and quality of life. Roche employs roughly 65’ 000 people in 150 countries. The Group has alliances and R&D agreements with numerous partners, including majority ownership interests in Genentech and Chugai.

Additional information
- Roche Diagnostics: www.roche-diagnostics.com
- Hitachi: www.hitachi.com