Major Shareholders

All shares in the Company are bearer shares, and for this reason the Company does not keep a register of shareholders. The following figures are based on information from shareholders, the shareholder validation check at the Annual General Meeting and on other information available to the Company.

• 80,020,000 (previous year 80,020,000) shares: Shareholders’ group with pooled voting rights, comprising Ms Vera Michalski-Hoffmann, Ms Maja Hoffmann, Mr André Hoffmann, Dr Andreas Oeri, Ms Sabine Duschmalé-Oeri, Ms Catherine Oeri, Ms Maja Oeri, Mr Jörg Duschmalé and Mr Lukas Duschmalé. ^a)
• 53,332,863 (previous year 53,332,863) shares (participation below 33 1/3%): Novartis International Ltd, Basel including Affiliates thereof.^b)

a) Information supplied by the shareholders. This figure of 80,020,000 shares does not include shares without pooled voting rights held outside the group by individual members of the group.
b) Figures as of 31 December 2005 supplied by Novartis International Ltd, Basel.