Investor Update

Basel, 19 December 2008

Roche announces update to its U.S. ADR facility

As of today, Roche's American Depositary Receipt (ADR) program (OTCQX: RHHBY) has moved from The Bank of New York Mellon to J.P. Morgan as depositary bank. The ADR facility, first launched in 1992, is based on Roche's non-voting equity security (ROG).

To further strengthen the program and its liquidity, the Roche ADR was upgraded for trading on the OTCQX International PremierQX platform in November 2007, the first large-cap company worldwide to be admitted.

Additionally, Roche expects to implement a change to its ADR ratio in the beginning of January 2009. Currently, one (1) ADR (RHHBY) represents one half (½) of one non-voting equity security (ROG), but once the ratio change is implemented, one (1) ADR will represent one quarter (1/4) of one non-voting equity security. It is expected that the ADR ratio change will be fully implemented no later than by mid-January 2009.

Expected key dates for the ADR ratio change:
5 Jan 2009    Record date
8 Jan 2009    Pay date
9 Jan 2009    Ex date (first day trading takes place with the new ADR ratio)

Roche's new ADR depositary bank J.P. Morgan is available for any current or potential Roche investor with questions about the above-mentioned changes. Please contact the J.P. Morgan service center at 1-800-990-1135.