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Investor Update

Basel, 2 June 2008

Reminder:  Invitation to Roche investor science event - phase IIb data on R1583 GLP-1 analogue and overall update on Roche´s franchise in diabetes & metabolism
Monday, 9 June 2008



We kindly invite investors and analysts to participate in an event to present and discuss new phase IIb data and results on R1583 GLP-1 analogue presented during the 2008 ADA (American Diabetes Association) Annual Scientific Sessions. Further, Roche will provide an overall update on its franchise in diabetes and metabolism.

The Roche investor science event will take place on:
Monday, 9 June 2008 from 6:30 pm to 8:00 pm Pacific Time

Hotel “W” San Francisco
181 3rd Street
San Francisco, California 94103
Room: Great Room 2

Following presentations and the Q&A session, Roche Investor Relations is inviting participants to stay for a light dinner. Additonally, during the dinner there will be an opportunity to attend a diagnostics experimentarium and explore Roche´s key products in Diabetes Care (blood glucose meters, insulin delivery systems and disease & information management solutions).

Please contact Misty Vita at misty.vita@roche.com immediately if you would like to attend this event or if you have any questions.



Conference call
Investors and analysts who cannot attend in person in San Francisco are also invited to join the accompanying conference call either by live audio webcast or by telephone.

Live audio webcast
The live conference call can be accessed via http://ir.roche.com. Following the event, an MP3 file will be made available for download.

Phone conference call
The live conference call can be accessed using the following dial-in numbers:
+41 91 610 5600 (Switzerland)
+44 207 107 0611 (UK)
+1 866 291 4166 (USA)
Please dial in to the conference call 10 – 15 minutes before the call is scheduled to start.

A replay of the conference call will be available one hour after the conference call and then for 48 hours. The replay can be accessed using the following dial-in numbers:
+41 91 612 4330 (Switzerland)
+44 207 108 6233 (UK)
+1 866 416 2558 (USA)
Enter the ID 17060 followed by the # sign

At the time of the conference call, the accompanying presentation will be available from the IR website at http://ir.roche.com.