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Investor Update

Basel, December 19, 2007

Roche's Full Year Results and Report for 2007

30 January - 8.00 CET - Morning Telephone Conference
30 January - 15.00 GMT - Presentation in London (16.00 CET)
1 February - 12.30 EST- Presentation in New York (18.30 CET)

Roche will publish its Full Year Results for 2007 prior to the opening of the Swiss Stock Exchange at 7.00 CET / 6.00 GMT / 1.00 am EST on January 30. Concurrently, the Full Year Presentation and Annual Report will be available from the Roche website http://ir.roche.com. We would like to invite all interested parties to dial in or participate in any of the scheduled events outlined below:

January 30, 2008

The Morning Telephone Conference is being held by senior management followed by a Q&A session at 8.00 CET / 7.00 GMT / 2.00 am EST.

Participants will be

Erich Hunziker, CFO and Deputy Head of the Corporate Executive Committee
William M. Burns, CEO Division Roche Pharma
Severin Schwan, CEO Division Roche Diagnostics
Karl Mahler, Head of Investor Relations

Please dial in to the conference 10-15 min prior to the scheduled start using the following numbers:
+41 91 610 56 00 (Europe and ROW) or +44 207 107 06 11 (UK) or +1 866 291 41 66 (USA)
Alternatively, a live audio webcast can be accessed via http://ir.roche.com.

The Full Year Presentation followed by Q&A and additional breakout sessions will be held at  the Grange City Hotel, 8-14 Cooper's Row, London EC3N 2BQ starting from 15.00 GMT / 16.00 CET / 10.00 am EST.

Participants will be

Franz B. Humer, Chairman of the Board of Directors and Chief Executive Officer
Erich Hunziker, CFO and Deputy Head of the Corporate Executive Committee
William M. Burns, CEO Division Roche Pharma
Severin Schwan, CEO Division Roche Diagnostics

The presentation can be followed by a live audio webcast accessible via http://ir.roche.com. Alternatively you can dial in to the conference using the following dial-in numbers (listen only mode, no live access to speakers):
+41 91 610 56 00 (Europe and ROW) or +44 207 107 06 11 (UK) or +1 866 291 41 66 (USA)

The breakout sessions covering the topics Strategy & Finance, Pharmaceuticals, Diagnostics and Accounting will be held following the main Q&A Session. With the exception of Strategy & Finance, each session will be repeated.

February 1, 2008

The Full Year Results Presentation, followed by Q&A and breakout sessions will be held at the Roosevelt Hotel, 45 East 45th Street (at Madison Avenue), New York 10017, starting from 12.30 pm EST / 17.30 GMT / 18.30 CET.

Participants will be

Franz B. Humer, Chairman of the Board of Directors and Chief Executive Officer
Erich Hunziker, CFO and Deputy Head of the Corporate Executive Committee
William M. Burns, CEO Division Roche Pharma
Severin Schwan, CEO Division Roche Diagnostics

The presentation can be followed by a live audio webcast, accessible via http://ir.roche.com. Alternatively you can dial in to the conference using the following dial-in numbers (listen only mode, no live access to speakers):
+41 91 610 56 00 (Europe and ROW) or +44 207 107 06 11 (UK) or +1 866 291 41 66 (USA)

The breakout sessions covering the topics Strategy &Finance, Pharmaceuticals, Diagnostics and Accounting will be held following the main Q&A Session. Apart from the one on Strategy & Finance, the sessions will be repeated once.

Replays

Replays will be available one hour after the respective event, for 48 hours. Access is by dialing:
+41 91 612 43 30 (Europe and ROW) or +44 207 108 62 33 or +1 866 416 25 58 (USA).

Please enter the conference ID followed by the # sign:
- Morning Telephone Conference: ID 418
- Presentation London: ID 424
- Presentation New York: ID 242

All webcasts will be available on demand at http://ir.roche.com.
The breakout sessions will be recorded and placed on the Roche website shortly after the events.