Investor Update

Basel, 6 December 2007

Genentech provides update from Avastin FDA Advisory Meeting

Dear Investor,
Genentech announced today that the Oncologic Drugs Advisory Committee (ODAC) appointed by the U.S. Food and Drug Administration (FDA) voted 5 to 4 that data are not sufficient to establish a favorable risk/benefit analysis for the use of Avastin (bevacizumab), in combination with paclitaxel chemotherapy, for the treatment of patients who have not received chemotherapy for their locally recurrent or metastatic HER2-negative breast cancer. The FDA is not bound by the recommendations of its advisory committees. The FDA is expected to make a decision on the supplemental Biologics License Application requesting approval for the use of Avastin in this patient population by February 23, 2008.

View the full Genentech press release

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