Investor Update

Basel, October 12, 2007

Invitation to event on Roche data & results at ACR 2007 and Roche´s emerging new franchise in autoimmune diseases
Friday, November 9, 2007

We kindly invite investors and analysts to participate in an event to present and discuss new data and results presented during the 2007 ACR conference (American College of Rheumatology) as well as to provide an update and status on Roche´s emerging new franchise in the area of autoimmune diseases.

The event will take place:
Friday, November 9, 2007 from 4:30 to 6:00 PM EST / 22:30 to 24:00 CET

Hilton Boston Financial District
89 Broad Street, Boston, Massachusetts, 02110
Kellogg Ballroom

Following the presentations and the Q&A session, Roche Investor Relations is inviting the participants to stay for a light dinner and an opportunity for informal discussions with key Roche representatives.

Please contact Misty Vita at misty.vita@roche.com before November 2, 2007 if you would like to attend this event.

Conference call
Investors and analysts who cannot attend in person are also invited to join the accompanying conference call either by live audio webcast or by telephone:

Live audio webcast
The live conference call can be accessed via ir.roche.com. Following the event, the MP3 file will be made available for download.

Phone conference call
The live conference call can be accessed using the following dial-in numbers:
+41 91 610 56 00 (Europe)
+44 207 107 0611 (UK)
+1 866 291 4166 (USA)
Please dial in to the conference call 10 – 15 minutes before the call is scheduled to start.

A replay of the conference call will be available one hour after the conference call and then for 48 hours. The replay can be accessed using the following dial-in numbers:
+41 91 612 4330 (Europe)
+44 207 108 6233 (UK)
+1 866 416 2558 (USA)
Enter the ID 284 followed by the # sign

At the time of the conference call, the accompanying presentation will be available from the IR website at ir.roche.com.