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Investor Update

Basel, 20 June 2006

Invitation to conference call on Roche data and results at EULAR 2006

Friday, June 23, 2006

We kindly invite you to participate in an analyst and investor conference call to present and discuss new data and results presented during the 2006 EULAR conference (The European League Against Rheumatism) on June 21-23 in Amsterdam, The Netherlands. The conference call will take place:

Friday, June 23, 2006 from 14:30 to 15:30 CET / 08:30 to 09:30 EST

Participants will be:

Dr. Karl Mahler, Head of Investor Relations, Roche
Dr. Urs Schleuniger, Business Director, Hematology & Autoimmune Diseases, Roche
Prof. Paul Emery, arc Professor of Rheumatology, Head of Musculoskeletal Unit, University of Leeds, UK
Prof. Edward C Keystone, Professor of Medicine, University of Toronto, Canada

Analysts and investors are invited to dial in to the conference call using the following dial-in numbers:

+41 (0) 91 610 56 00 (Europe and ROW)
+44 (0) 207 107 06 11 (UK )
+1 (1) 866 291 41 66 (USA Toll Free)

Please dial in to the conference call 10 – 15 minutes before the call is scheduled to start.

Alternatively, a live audio webcast can be accessed via http://ir.roche.com.

Ahead of the call, the presentation will be available from the IR website at http://ir.roche.com.

A replay of the conference call will be available one hour after the conference call, for 48 hours.
Access is by dialling:

+41 (0) 91 612 43 30 (Europe and ROW)
+44  (0) 207 108 62 33 (UK )
+1 (1) 866 416 25 58 (USA)

Listeners will be asked to enter the ID 487 followed by the # sign.