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Investor Update

Basel, 20 October 2005

Invitation to Roche Analyst Briefing at American College of Rheumatology Meeting, November 16th

We are pleased to invite you to an analyst briefing discussing data presented by Roche and its partners at the annual meeting of the American College of Rheumatology (ACR) in San Diego.

Date:Wednesday, November 16th, 2005
Time:6:30 p.m. to 8:00 p.m. PST (Pacific Standard Time)
3:30 a.m. to 5:00 a.m. CET (Central European Time), November 17th
Venue:Manchester Grand Hyatt San Diego
1 Market Place
San Diego, CA 92101
USA
Phone: +1 619 232 1234
Fax: +1 619 233 6464

The event will also be webcast. The replay and the presentation slides can be downloaded after the event via the Roche Internet site ir.roche.com.

Please complete the accompanying response form indicating your intention to attend. If you have any questions please contact Claudia Nyffenegger, Gaby Strausak or Zuzana Dobbie at +41-61-688-88-80.

Thank you for your continuing interest in Roche. We look forward to meeting you at this event.