Investor Updates

19. December 2008
Roche announces update to its U.S. ADR facility
As of today, Roche's American Depositary Receipt (ADR) program (OTCQX: RHHBY) has moved from The Bank of New York Mellon ... more

19. December 2008
MabThera inhibits the destruction of joints in patients with early rheumatoid arthritis
Roche announced today that the radiographic IMAGE study investigating MabThera (rituximab) in combination with methotrexate ... more

16. December 2008
Avastin filed in Europe for treatment of patients with the most aggressive form of brain cancer
Roche announced today the filing of its anti-angiogenic cancer treatment Avastin (bevacizumab) for the treatment of patients ... more

15. December 2008
Xeloda shows strong promise in early breast cancer
Data presented at the San Antonio Breast Cancer Symposium (SABCS) indicate that adding Xeloda to standard chemotherapy allows ... more

11. December 2008
Herceptin given prior to surgery improves the chance of survival without relapse for women with HER2-positive breast cancer
About 70% of women with locally advanced HER2-positive breast cancer were free of their disease three years after initiation ... more

10. December 2008
New data show that Herceptin, Xeloda and Avastin help patients with early and advanced breast cancer live longer or remain disease free for longer
New data being presented at the 31st Annual San Antonio Breast Cancer Symposium (SABCS) show that Herceptin (trastuzumab), ... more

10. December 2008
MabThera maintenance therapy in lymphoma patients stops cancer coming back for nearly three times as long as chemotherapy alone
New data presented at the 50th Annual Meeting of the American Society of Hematology (ASH) confirm that patients with recurrent ... more

09. December 2008
First glyco-engineered and humanized monoclonal antibody in clinical trials could offer hope for difficult to treat lymphoma patients
Roche shows promising early results for its third-generation monoclonal antibody for CD20-positive hematological malignancies more

08. December 2008
Reminder: Invitation to Roche investor science event from ASH 2008
We kindly invite investors and analysts to participate in a conference call to discuss new clinical data and results presented ... more

08. December 2008
New phase III data suggest MabThera is a highly effective treatment for patients with idiopathic thrombocytopenic purpura
New data presented at the 50th Annual Meeting of the American Society of Hematology (ASH) today show that people living with ... more

07. December 2008
New data show MabThera enables leukemia patients to live longer without their disease progressing
New data from two pivotal phase III studies to be presented at the Annual Meeting of the American Society of Hematology in ... more

04. December 2008
Roche and FDA Agree on Pathway Towards U.S. Approval of ACTEMRA (tocilizumab)
Roche today announced that the U.S. Food and Drug Administration (FDA) has provided further guidance on the requirements for ... more

04. December 2008
European Commission approval of new indication for Roche’s Pegasys offers hepatitis C patients a second chance for a cure
Roche announced today that the European Commission has approved Pegasys (peginterferon alfa-2a [40 KD]) plus Copegus (ribavirin) ... more

26. November 2008
Anti-malignancy agent / anti-VEGF humanised monoclonal antibody, Avastin Application for Approval of Additional Indication of NSCLC
Chugai Pharmaceutical Co., Ltd. announced today that the company filed an application with the Japanese Ministry of Health, ... more

25. November 2008
Roche signs definitive agreement to acquire Memory Pharmaceuticals
Roche and Memory Pharmaceuticals today announced that the two companies have signed a definitive merger agreement for Roche ... more

24. November 2008
New phase III study of Avastin in advanced breast cancer meets its primary endpoint of increasing the time patients live without their disease getting worse
Third study confirming the benefit of Avastin in breast cancer shows that Avastin can be effectively combined with commonly ... more

21. November 2008
RoActemra Receives Positive Opinion in Europe for the Treatment of Rheumatoid Arthritis
Roche today announced that the European Committee on Human Medicinal Products (CHMP) has given a positive recommendation for ... more

21. November 2008
Study of MabThera in the most common form of adult leukaemia selected as late-breaking abstract for the ASH annual meeting
Roche announced today that full results of the pivotal REACH study will be presented as part of the late breaker abstract ... more

14. November 2008
Tarceva-Avastin combination doubles time that patients with advanced lung cancer live without their disease progressing
Results of the phase III BeTa Lung study investigating the addition of Avastin (bevacizumab) to Tarceva (erlotinib) for the ... more

13. November 2008
Avastin gives an additional 4 months of life to patients with one of the most common types of lung cancer
Roche announced today that an exploratory analysis of the pivotal phase III E4599 study demonstrated that Avastin (bevacizumab) ... more

10. November 2008
Invitation to Roche investor science event from ASH 2008 - Conference call on 9 December 2008
We kindly invite investors and analysts to participate in a conference call to discuss new clinical data and results presented ... more

07. November 2008
Tarceva brings new hope to patients with advanced non-small cell lung cancer
Roche today announced that the SATURN (SequentiAl Tarceva in UnResectable NSCLC) study met its primary endpoint of progression ... more

03. November 2008
Avastin filed in U.S. for treatment of patients with the most aggressive form of brain cancer
Roche announced today that its U.S. partner Genentech submitted a supplemental Biologics License Application (sBLA) to the ... more

03. November 2008
Renewed hope for a cure: Extending Pegasys treatment to 72 weeks provides new treatment option for difficult-to-treat hepatitis C patients
Three new studies presented at AASLD demonstrate efficacy and safety of extended treatment in non-responders, relapsers and ... more

03. November 2008
New study shows that Pegasys provides higher cure rates for hepatitis C patients
A new, independently conducted study presented at the American Association for the Study of Liver Disease conference, AASLD, ... more

27. October 2008
Study shows MabThera continues to improve patient response in rheumatoid arthritis with multiple courses of treatment
A study has shown that rheumatoid arthritis patients given multiple courses of MabThera experienced further improvements in ... more

27. October 2008
New data shows ACTEMRA inhibits progression of joint destruction and improves physical function of patients with Rheumatoid Arthritis
Roche announced today that the innovative new therapy ACTEMRA (tocilizumab) can significantly inhibit structural damage to ... more

20. October 2008
Variety of studies on Roche's Rheumatoid Arthritis portfolio to be presented at the American College of Rheumatology Annual Scientific Meeting
Roche today announced that a total of 15 abstracts involving its investigational rheumatoid arthritis (RA) treatment Actemra ... more

20. October 2008
Reminder: Roche's Third Quarter Sales 2008 Conference Call Tuesday October 21st, 2008
Roche will publish its Sales Results for the 3rd Quarter of 2008 prior to the opening of the Swiss Stock Exchange on Tuesday ... more

07. October 2008
Pivotal Phase III study shows MabThera delays disease progression in patients with relapsed or refractory Chronic Lymphocytic Leukaemia
Roche announced today that a Phase III study investigating MabThera (rituximab) in combination with chemotherapy has shown ... more

06. October 2008
Roche announces topline outcomes for Avastin-Tarceva combination study in advanced lung cancer
Phase III data shows evidence of potential benefit for patients with advanced lung cancer. Roche today announced topline results ... more

03. October 2008
Genentech, Glycart and Roche enter into collaboration agreement for potential cancer therapy
Genentech, Inc. (NYSE: DNA), GlycArt, a company wholly-owned by Roche, and Roche (SWX: ROG) have entered into a collaboration ... more

02. October 2008
Actemra significantly improves the debilitating symptoms of Rheumatoid Arthritis in patients who do not adequately respond to standard therapies
The innovative rheumatoid arthritis drug Actemra (tocilizumab) has been shown to significantly improve the signs and symptoms ... more

22. September 2008
Roche's Third Quarter Sales 2008 Conference Call Tuesday October 21st, 2008
Roche will publish its Sales Results for the 3rd Quarter of 2008 prior to the opening of the Swiss Stock Exchange on Tuesday ... more

18. September 2008
FDA issues complete response letter to Roche for Actemra Biologics License Application
Roche today announced that the U.S. Food and Drug Administration (FDA) has issued a complete response letter for the Biologics ... more

16. September 2008
Avastin: only biologic to demonstrate significant survival benefit in first-line and second-line metastatic colorectal cancer patients
Data presented at the 33rd Congress of the European Society for Medical Oncology (ESMO) confirmed that Avastin in combination ... more

15. September 2008
Final analysis of Phase III trial confirms benefit of Avastin in Lung cancer
The final analysis of the pivotal phase III Roche-sponsored AVAiL (Avastin in lung) study in patients with previously untreated, ... more

15. August 2008
Roche and the wider global community: making a lasting difference to people’s lives
Progress report on new initiatives in providing Access to Medicine and encouraging scientists more

15. August 2008
Roche and Meda agree on product transactions
Divestment of four Roche pharmaceutical products to Meda underlines strong focus on key therapy areas more

31. July 2008
Full reconciliation of Chugai interim results into IFRS
Results of Chugai as consolidated by the Roche Group more

31. July 2008
Toll Manufacturing Agreement for the Bulk Drug Substance of Actemra, a Humanized Anti-Human IL-6 Receptor Monoclonal Antibody
Please find enclosed a press release by Chugai. more

31. July 2008
MabThera filed in the EU for treatment of most common leukaemia in adults
Submission based on Phase III study showing superior results for MabThera in Chronic Lymphocytic Leukaemia (CLL) when added ... more

30. July 2008
FDA Advisory Committee recommends approval of Actemra for the treatment of rheumatoid arthritis
Roche announced that the Arthritis Advisory Committee of the U.S. Food and Drug Administration (FDA) by a near unanimous (10-1) ... more

28. July 2008
Avastin filed for broader breast cancer label in Europe
Roche announced today that they have submitted an application to the EMEA to extend the current European label of Avastin ... more

23. July 2008
Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics
Roche and ARIUS Research Inc. today announced that the two companies have signed a definitive agreement for Roche to acquire ... more

22. July 2008
Reminder: Roche Investor Events: AACC 2008
more

21. July 2008
Roche posts very good results: strong market outperformance - guidance confirmed
more

21. July 2008
Roche makes offer to acquire all outstanding shares of Genentech for US $89.00 per share in cash
Combination to enhance innovation by allowing for diversity of research approaches while also encouraging sharing of IP, technologies, ... more

20. July 2008
Roche Half-Year Results 2008 brought forward to Monday, 21 July 2008
We wish to inform you that the Half-Year Results for 2008 will now be published prior to opening of the Swiss Stock exchange ... more

02. July 2008
Roche Investor Events: AACC 2008
more

30. June 2008
Avastin shows unprecedented benefits in colorectal cancer patients, irrespective of K-Ras gene mutation
Data presented today at the 10th World Congress on Gastrointestinal Cancer (WCGC) in Barcelona confirm that Avastin (bevacizumab) ... more

27. June 2008
Roche's Half Year Results for 2008
Roche will publish its Half Year Results for 2008 prior to the opening of the Swiss Stock Exchange on July 24 at 7.00 CET ... more

27. June 2008
Introducing Roche's new Finance Information System
Roche today announced that it has launched on its Investor Relations homepage an innovative online tool to facilitate and ... more

26. June 2008
European approval for Roche`s Pegasys personalises treatment for a subgroup of hepatitis C patients: chance for cure with only four months of treatment
more

24. June 2008
Roche`s tender offer to increase ownership stake in Chugai successful
Roche today announced that its ownership stake in Chugai will increase from 50.1% to 59.9% following the successful completion ... more

13. June 2008
New data reveals Actemra is the first and only biologic drug to show superiority over current standard of care in rheumatoid arthritis
more

11. June 2008
New evidence shows MabThera is more effective than a second TNF inhibitor in rheumatoid arthritis patients who have interrupted anti-TNF therapy due to lack of efficacy
New data also proves MabThera’s inhibition of joint damage is maintained over two years more

10. June 2008
Roche moves investigational diabetes drug, Taspoglutide, into Phase III clinical trials
Positive Phase II results of Roche and Ipsen’s first once-weekly human GLP-1 presented at the American Diabetes Association ... more

06. June 2008
Roche Investor Science Event: EULAR 2008
nvitation to Roche’s analyst briefing on Actemra and MabThera Friday, June 13th 2008 in Paris more

04. June 2008
Significant new data on Roche’s Rheumatoid Arthritis portfolio to be presented at the EULAR Annual Meeting 2008
more

02. June 2008
Reminder: Invitation to Roche investor science event - phase IIb data on R1583 GLP-1 analogue and overall update on Roche's franchise in diabetes & metabolism Monday, 9 June 2008
We kindly invite investors and analysts to participate in an event to present and discuss new phase IIb data and results on ... more

31. May 2008
Second phase III study of Avastin plus chemotherapy shows improved progression-free survival in women with advanced HER2-negative breast cancer
Avastin (bevacizumab), significantly improves the time patients with metastatic breast cancer live without their disease getting ... more

31. May 2008
Benefits of Avastin in metastatic colorectal cancer further substantiated
A wealth of new Avastin (bevacizumab) data were presented at the 44th Annual Meeting of the American Society of Clinical Oncology ... more

30. May 2008
Pertuzumab with Herceptin shows impressive results in women with advanced HER2-positive breast cancer
New data from a Phase II trial presented at the American Society of Clinical Oncology (ASCO) 2008 meeting in Chicago show ... more

23. May 2008
Reminder - Roche Science Events: ASCO 2008 - Analyst briefings on data presented at ASCO
We are pleased to invite you to our Analyst briefings to discuss data presented by Roche at the American Society of Clinical ... more

22. May 2008
Roche to increase its stake in Chugai from 50.1% to 59.9%
Roche announced today that it intends to increase its stake in Chugai from 50.1% to 59.9%. Roche has invited Chugai shareholders ... more

20. May 2008
Roche Investor Science Event EULAR 2008
Invitation to Roche`s analyst briefing on Actemra and MabThera -Friday, June 13th 2008 in Paris more

20. May 2008
Roche ASCO planner
Roche and its collaborators will present a large number of abstracts on its broad oncology portfolio at the Annual Meeting ... more

16. May 2008
New Roche data to be presented at ASCO offers further hope for cancer patients
more

16. May 2008
Invitation to Roche investor science event - phase IIb data on R1583 GLP-1 analogue and overall update on Roche´s franchise in diabetes & metabolism
We kindly invite investors and analysts to participate in an event to present and discuss new phase IIb data and results on ... more

16. May 2008
Genentech provides update on Avastin Program
Overview provided for studies to be presented at the 2008 American Society of Clinical Oncology Annual Meeting; and updated ... more

09. May 2008
Actemra inhibits joint damage and improves physical function of patients with Rheumatoid Arthritis
Roche announced today that Actemra (tocilizumab) can significantly inhibit structural damage to joints in patients with rheumatoid ... more

05. May 2008
Roche Science Events: ASCO 2008
We are pleased to invite you to our Analyst briefings to discuss data presented by Roche at the American Society of Clinical ... more

29. April 2008
Genentech and Biogen Idec Announce Top-Line Results From Phase II/III Clinical Study of Rituxan in Systemic Lupus Erythematosus
Genentech and Biogen Idec announced today top-line results from a phase II/III clinical study of Rituxan in Systemic Lupus ... more

28. April 2008
Three Studies Presented at 43rd EASL Strongly Indicate Better Efficacy for PEGASYS in Curing Hepatitis C
Roche today announced that compelling new data from three studies indicate that chronic hepatitis C patients who received ... more

28. April 2008
Roche`s R1626, First-in-Class Hepatitis C Polymerase Inhibitor, Demonstrates Impressive End-of-Treatment Response in Phase IIa Study
Roche`s investigational treatment for hepatitis C, R1626, has shown an impressive end-of-treatment response rate when given ... more

21. April 2008
Roche provides update on a phase III study (AVAiL) of Avastin plus chemotherapy in first-line, advanced, non-squamous, non-small cell lung cancer
Roche today announced an update of the previously reported phase III clinical study (AVAiL) of Avastin (bevacizumab), which ... more

18. April 2008
Herceptin helps eradicate HER2-positive breast tumours when given before surgery
New data presented today as part of a late breaking plenary session at EBCC in Berlin showed that Herceptin (trastuzumab) ... more

17. April 2008
Roche continues solid sales growth in first quarter of 2008 - both divisions significantly outpace their markets
Double-digit growth of key products more than outweighs one-time impact of major Tamiflu pandemic orders in year-earlier period more

16. April 2008
Reminder: Roche`s First Quarter Sales 2008 Conference Call
Roche will publish its Sales Results for the 1st Quarter of 2008 prior to the opening of the Swiss Stock Exchange on Thursday ... more

16. April 2008
Actemra approved in Japan to treat patients with rheumatoid arthritis
Roche announced today that their alliance partner company Chugai has received approval in Japan for the use of its innovative ... more

15. April 2008
Roche fully acquires privately-owned biotech company Piramed
Roche announced today that it will acquire Piramed Limited, a privately-owned UK company focusing on therapeutics targeting ... more

01. April 2008
InterMune announces top-line results of phase 1b trial of itmn-191 (R7227) and provides program update
InterMune, Inc. (Nasdaq: ITMN) today provided an overall program update and reported the top-line results from the four dose ... more

01. April 2008
Phase II pooled safety results of Roche's investigational CETP inhibitor presented at the American College of Cardiology
more

31. March 2008
Reminder: Roche Science Event - Conference Call from ACC
more

25. March 2008
Roche`s First Quarter Sales 2008 Conference Call
Roche will publish its Sales Results for the 1st Quarter of 2008 prior to the opening of the Swiss Stock Exchange on Thursday ... more

25. March 2008
Novel drug ACTEMRA significantly improves the debilitating symptoms of Rheumatoid Arthritis in patients who have an inadequate response to standard therapy
more

17. March 2008
Roche Science Event Conference Call from ACC
We are pleased to invite you to a Conference Call discussing data on Roche`s CETP inhibitor R1658 presented at the American ... more

04. March 2008
Roche raises dividend by 35 percent
Annual General Meeting approves Annual Report and financial statements for 2007 more

29. February 2008
Combination therapy of anti-cancer agents Xeloda, oxaliplatin and Avastin, and Xeloda monotherapy filed for advanced or recurrent colorectal cancer in Japan
Chugai Pharmaceutical Co. announced today that it filed an application with the Japanese Ministry of Health, Labour and Welfare ... more

29. February 2008
Herceptin approved in Japan for early treatment in patients with HER2-positive breast cancer
Roche announced today that its majority-owned subsidiary Chugai Pharmaceutical Co. Ltd received approval from the Japanese ... more

25. February 2008
FDA grants accelerated approval of Avastin in combination with paclitaxel chemotherapy for first-line treatment of patients with advanced HER2-negative breast cancer
Roche today announced that Genentech has received U.S. Food and Drug Administration (FDA) accelerated approval for Avastin® ... more

19. February 2008
Roche Completes Tender Offer for Ventana Shares
Roche (SWX: ROG.VX; RO.S; OTCQX; RHHBY) and Ventana Medical Systems Inc. (NASDAQ: VMSI) today announced that Roche has completed ... more

13. February 2008
Second phase III study of Avastin in 1st line metastatic breast cancer meets its primary endpoint
Roche announced today that a phase III study in metastatic breast cancer investigating Avastin (bevacizumab) in combination ... more

08. February 2008
Roche purchases shares in tender offer for Ventana
Roche today announced that its wholly-owned subsidiary Rocket Acquisition Corporation has accepted for payment all shares ... more

04. February 2008
EU Grants Broad Approval of Xeloda for Patients with Metastatic Colorectal Cancer
Roche announced today that the European Commission has approved its oral chemotherapy Xeloda (capecitabine) for the treatment ... more

30. January 2008
Record operating results for Roche again in 2007
Earnings per share grow twice as fast as sales - Double-digit sales growth for seventh year in succession - Sharp 35% dividend ... more

29. January 2008
Reminder: Roche`s Full Year Results and Report for 2007
Roche will publish its Full Year Results for 2007 prior to the opening of the Swiss Stock Exchange at 7.00 CET / 6.00 GMT ... more

28. January 2008
Avastin receives broad label extension in Europe for the treatment of patients with metastatic colorectal cancer
Many more patients can now benefit from Avastin's proven survival benefits. Roche announced today that the European Commission ... more

25. January 2008
MabThera increases the time patients with the most common form of adult leukaemia live without their cancer progressing
Pivotal Phase III study with MabThera reaches primary endpoint in first line treatment for patients with Chronic Lymphocytic ... more

25. January 2008
MabThera meets study primary endpoint in improving disease symptoms when used as first biologic therapy in patients with rheumatoid arthritis
First Phase III study demonstrating the potential of MabThera when used earlier in the course of treatment. Roche announced ... more

22. January 2008
Roche to Acquire Ventana for $89.50 per share
Roche and Ventana Reach Definitive Merger Agreement more

16. January 2008
Reminder: Roche`s Full Year Results and Report for 2007
Roche will publish its Full Year Results for 2007 prior to the opening of the Swiss Stock Exchange at 7.00 CET / 6.00 GMT ... more

08. January 2008
Pharmasset announces R7128 achieves 85% rapid virologic response in a 4-week combination study for the treatment of chronic hepatitic C
Pharmasset announced today the preliminary results of a 4-week Phase 1 clinical trial to evaluate two oral dose levels of ... more