Student Internship in Preclinical Process Research (September 2017, 6 months)

Switzerland, Basel-Town, Basel

The Process Research & Supply unit of the pCMC (preclinical Chemistry, Manufacturing and Control) department is responsible for supporting projects from lead optimization up to Phase I enabling toxicological studies. Our tasks include the preparation of key building blocks in the early phase of the projects but later focus on the supply of drug candidates (small molecules and peptides) for formulation, DMPK and toxicological studies. To do so we engage into the troubleshooting of the Discovery Chemistry synthesis, we find shortcuts or develop new synthetic routes to allow a fast, reliable, safe, and robust supply of the desired drug candidates in amounts ranging from gram to several kilograms. By doing so, our goal is also to provide synthetic routes and processes amendable to scale up for the first Good Manufacturing Practice campaign led by our colleagues of late stage development.

During your stay in Process Research & Supply you will:

  • Learn how to transition a lab scale reaction/synthesis into a scalable route
  • Design robust processes & syntheses to be ran in multi kg scale
  • Be part of a 3-4 chemists team under the supervision of a laboratory head and the guidance of the team members
  • Be exposed to state of the art laboratory and analytical equipment as well as technologies such as automated reactors, in-line FTIR spectroscopy or continuous processing