Large Molecule Research (LMR) in Roche Pharma Research and Early Development (Roche pRED) is responsible for providing innovative protein therapeutics for all Roche pRED Discovery and Translational areas (DTAs). The scope of our activities extends from the generation of new molecules up to the production of the clinical material for phase I. The department Immune Biology is responsible for designing immunization campaigns customized to the desired target product profiles, performing the immunizations and characterizing immune responses of the animals. We also continuously optimize Roche's immunization platform by establishing alternative methods to immunize and generate antibodies. One of the key immunization platforms the department of Immune Biology owns and continuously improves is the generation of human antibodies from single peripheral B cells from our proprietary transgenic rabbits using an elaborate B-cell cloning process and a robust B-cell PCR workflow. These platform technologies are fully automated and optimized to achieve maximum throughput with excellent precision to ensure the identification of highly differentiated antibody therapeutics.
Key responsibilities include, but are not limited to the following tasks:
- You will be leading a team of 4 direct reports and an organization with roughly 15-20 employees
- You are a direct report to the Head Discovery LMR and a member of the extended LMR Leadership Team
- This leadership role includes all aspects with regard to coordination, management and strategic planning, performance management, coaching and continuous optimization of the entire organization
- One of your reports leads the in vivo immunization group which carries out all immunizations for pRED and, in part, also for the Roche Professional Diagnostic group in Penzberg.
- Being an expert in pre-Lead ID and project teams and advising and defining together with the responsible LMR program managers the teams on the adequate immunization strategies.
- Continuous advancement and automation of the core technologies and scientific excellence of the technology unit (in particular immunological questions concerning antibody responses and alternative immunization protocols for difficult antigens).
- Support (Coaching/Mentoring) of the technical and operational work of the groups of the department as well as participation in the relevant matrix management committees
- Responsibility for evaluating and designing new biotherapeutic treatment approaches and concepts.
- Being the internal and external representative of the technology unit, e.g., exchange with DTAs and other internal functions.
- Responsibility for complying with regulations and guidelines on industrial safety and environmental protection as well as for other official regulations.